Tumour lineage shapes BRCA-mediated phenotypes

Jonsson, P; Bandlamudi, C; Cheng, ML; Srinivasan, P; Chavan, SS; Friedman, ND; Rosen, EY; Richards, AL; Bouvier, N; Selcuklu, SD; Bielski, CM; Abida, W; Mandelker, D; Birsoy, O; Zhang, LY; Zehir, A; Donoghue, MTA; Baselga, J; Offit, K; Scher, HI; O'R

Berger, MF; Solit, DB; Taylor, BS (reprint author), Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Oncol, 1275 York Ave, New York, NY 10021 USA.; Solit, DB; Taylor, BS (reprint author), Mem Sloan Kettering Canc Ctr, Human Oncol & Patho

NATURE, 2019; 571 (7766): 576

Abstract

Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers(1-3), and disease-specific screening and preventative strategies have reduced c......

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