Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance

Evans, N; Grygorash, R; Williams, P; Kyle, A; Kantner, T; Pathak, R; Sheng, XB; Simoes, F; Makwana, H; Resende, R; de Juan, E; Jenkins, A; Morris, D; Michelet, A; Jewitt, F; Rudge, F; Camper, N; Manin, A; McDowell, W; Pabst, M; Godwin, A; Frigerio, M; Bird, M

Evans, N (通讯作者)，Abzena Ltd, Babraham Res Campus, Babraham, England.

FRONTIERS IN PHARMACOLOGY, 2022; 13 ():

Abstract

Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field m......

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