Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy

Wang, SJ; Zhao, ZJ; Fan, YH; Zhang, MM; Feng, XY; Lin, J; Hu, JQ; Cheng, Z; Sun, C; Liu, TT; Xiong, ZY; Yang, Z; Wang, HC; Sun, DD

Sun, DD (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.; Wang, HC (reprint author), Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2019; 1865 (7): 1905

Abstract

Mitochondrial dysfunction contributes to heart failure induced mortality in approximately 80% of diabetic patients. Mitophagy degrades defective mitoc......

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