Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

Finnberg, NK; Gokare, P; Lev, A; Grivennikov, SI; MacFarlane, AW; Campbell, KS; Winters, RM; Kaputa, K; Farma, JM; Abbas, AE; Grasso, L; Nicolaides, NC; El-Deiry, WS

El-Deiry, WS (reprint author), Fox Chase Canc Ctr, Dept Hematol Oncol, 7701 Burholme Ave, Philadelphia, PA 19111 USA.; El-Deiry, WS (reprint author), Fox Chase Canc Ctr, Mol Therapeut Program, Lab Translat Oncol & Expt Canc Therapeut, 7701 Burholme Ave, P

ONCOTARGET, 2017; 8 (40): 66747

Abstract

We have developed 3D-tumoroids and tumor slice in vitro culture systems from surgical tumor specimens derived from patients with colorectal cancer (CR......

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