NCTR25 fusion facilitates the formation of TRAIL polymers that selectively activate TRAIL receptors with higher potency and efficacy than TRAIL

Wang, Y; Lei, Q; Shen, CJ; Wang, N

Wang, N (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab New Drug Mech & Pharmacol Evaluat, 1st Xiannongtan St, Beijing 100050, Peoples R China.

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2021; 88 (2): 289

Abstract

Purpose Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptor (DR) 4 and DR5 and induces tumor-selective apoptosis. ......

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