HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B; Huda, N; Chen, XY; Antoine, DJ; Li, Y; Dai, GL; Kohler, UA; Zong, WX; Waguri, S; Werner, S; Oury, TD; Gong, Z; Yin, XM

Yin, XM (reprint author), Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2018; 128 (6): 2419

Abstract

Autophagy is important for liver homeostasis, and the deficiency leads to injury, inflammation, ductular reaction (DR), fibrosis, and tumorigenesis. I......

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