Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma

Ding, XW; Zhang, YY; Huang, TL; Xu, GF; Peng, CY; Chen, G; Kong, B; Friess, H; Shen, SS; Lv, Y; Roberts, LR; Wang, L; Zou, XP

Zou, XP (reprint author), Nanjing Med Univ, Nanjing Drum Tower Hosp, Clin Coll, Dept Gastroenterol, Nanjing 210008, Jiangsu, Peoples R China.

AMERICAN JOURNAL OF CANCER RESEARCH, 2019; 9 (3): 546

Abstract

Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-su......

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