Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development

Harbeson, SL; Morgan, AJ; Liu, JF; Aslanian, AM; Nguyen, S; Bridson, GW; Brummel, CL; Wu, LJ; Tung, RD; Pilja, L; Braman, V; Uttamsingh, V

Harbeson, SL (reprint author), Concert Pharmaceut Inc, 99 Hayden Ave,Suite 500, Lexington, MA 02421 USA.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017; 362 (2): 359

Abstract

Ivacaftor is currently used for the treatment of cystic fibrosis as both monotherapy (Kalydeco; Vertex Pharmaceuticals, Boston, MA) and combination th......

Full Text Link