Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

Reiberger, R; Radilova, K; Kral, M; Zima, V; Majer, P; Brynda, J; Dracinsky, M; Konvalinka, J; Kozisek, M; Machara, A

Kozisek, M; Machara, A (corresponding author), Czech Acad Sci, Gilead Sci & IOCB Res Ctr, Inst Organ Chem & Biochem, Flemingovo 2, Prague 16610, Czech Republic.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021; 22 (14):

Abstract

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved d......

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