Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Olson, CM; Jiang, BS; Erb, MA; Liang, YK; Doctor, ZM; Zhang, ZN; Zhang, TH; Kwiatkowski, N; Boukhali, M; Green, JL; Haas, W; Nomanbhoy, T; Fischer, ES; Young, RA; Bradner, JE; Winter, GE; Gray, NS

Gray, NS (reprint author), Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.; Gray, NS (reprint author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.

NATURE CHEMICAL BIOLOGY, 2018; 14 (2): 163

Abstract

Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for can......

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