Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists

Kindon, N; Andrews, G; Baxter, A; Cheshire, D; Hemsley, P; Johnson, T; Liu, YZ; McGinnity, D; McHale, M; Mete, A; Reuberson, J; Roberts, B; Steele, J; Teobald, B; Unitt, J; Vaughan, D; Walters, I; Stocks, MJ

Stocks, MJ (reprint author), AstraZeneca R&D Charnwood, Bakewell Rd, Loughborough LE11 5RH, Leics, England.; Stocks, MJ (reprint author), Univ Nottingham, Sch Pharm, Ctr Biomol Sci, Univ Pk, Nottingham NG7 2RD, England.

ACS MEDICINAL CHEMISTRY LETTERS, 2017; 8 (9): 981

Abstract

N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS)......

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