CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes

Schelling, MA; Nguyen, GT; Sashital, DG

Sashital, DG (通讯作者),Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA.

PLOS BIOLOGY, 2023; 21 (4):

Abstract

CRISPR-mediated interference relies on complementarity between a guiding CRISPR RNA (crRNA) and target nucleic acids to provide defense against bacter......

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