USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma

Zhang, HJ; Han, B; Lu, HL; Zhao, YB; Chen, XS; Meng, QW; Cao, MR; Cai, L; Hu, J

Cai, L; Hu, J (reprint author), Harbin Med Univ, Canc Hosp, Dept Internal Med Oncol 4, Harbin, Heilongjiang, Peoples R China.

CANCER LETTERS, 2018; 433 (): 186

Abstract

As a newly discovered deubiquitinating enzyme, ubiquitin-specific protease 22 (USP22) is predictive of therapeutic outcomes in individual cancer patie......

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