Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer

Raman, R; Villefranc, JA; Ullmann, TM; Thiesmeyer, J; Anelli, V; Yao, J; Hurley, JR; Pauli, C; Bareja, R; Eng, KW; Dorsaint, P; Wilkes, DC; Beg, S; Kudman, S; Shaw, R; Churchill, M; Ahmed, A; Keefer, L; Misner, I; Nichol, D; Gumpeni, N; Scognamiglio, T; Rubin, MA; Grandori, C; Solomon, JP; Song, W; Mosquera, JM; Dephoure, N; Sboner, A; Elemento, O; Houvras, Y

Houvras, Y (通讯作者)，Weill Cornell Med Coll, Dept Surg, New York, NY 10021 USA.;Houvras, Y (通讯作者)，Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA.

JOURNAL OF EXPERIMENTAL MEDICINE, 2022; 219 (6):

Abstract

Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer.......

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