BMJ:年轻人腹股沟持续疼痛,警惕股骨头坏死!——案例报道

2016-10-12 MedSci MedSci原创

患者男,23岁,有镰状细胞疾病;近两年来,腹股沟疼痛恶化、双侧臀部僵硬,因此就诊。 患者的关节没有受到牵连,既往也没有镰状细胞病相关的疾病史,但髋关节运动受限范围。 骨盆平片如下。 血红蛋白 90 g/L。外周血涂片显示呈镰刀状细胞、有核红细胞和细胞碎片。血红蛋白电泳显示高水平的血红蛋白S(65%),血清胆红素为17.1μmol/L。其余实验室检查没有异常。 患者诊断为

患者男,23岁,有镰状细胞疾病;近两年来,腹股沟疼痛恶化、双侧臀部僵硬,因此就诊。

患者的关节没有受到牵连,既往也没有镰状细胞病相关的疾病史,但髋关节运动受限范围。

骨盆平片如下。



血红蛋白 90 g/L。外周血涂片显示呈镰刀状细胞、有核红细胞和细胞碎片。血红蛋白电泳显示高水平的血红蛋白S(65%),血清胆红素为17.1μmol/L。其余实验室检查没有异常。

患者诊断为:双侧股骨头坏死,继发于髋关节骨性关节炎

鉴别诊断包括原发性骨关节炎、炎症性关节炎、骨关节炎进展迅速、软骨下机能不全性骨折、髋关节暂时性骨质疏松症。

股骨头坏死的常用影像学评估包括平片、磁共振成像、骨扫描和CT。

常见的平片变现为斑片状或不透明的轻微骨质疏松区,其次是囊性变及硬化或软骨下骨折(新月征)。如下图所示。





治疗股骨头坏死的目的是防止股骨头塌陷。在早期阶段可以使用药物治疗、生物物理治疗或进行髋关节保护手术。疾病晚期阶段则需要行人工全髋关节置换术。

本案例患者进行了全髋关节置换术,此后随访1年,患者没有再发疼痛,也没有再出现任何的活动受限。患者的Harris髋关节评分改善相当显著,从术前的34分,到术后1年的86分。

原始出处:

Raju Vaishya,et al.Bilateral groin pain in a young man.MJ 2016; 355 doi: http://dx.doi.org/10.1136/bmj.i5025 (Published 11 October 2016)

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    2017-01-15 仁心济世
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    2016-10-20 zmjlilei

    感谢分享一下

    0

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objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Oct 15 09:06:02 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148402, encodeId=133314840233, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 15 00:42:19 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362812, encodeId=4207136281238, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584873, encodeId=74c315848e3d7, content=<a href='/topic/show?id=931581e97ad' target=_blank style='color:#2F92EE;'>#股骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81797, encryptionId=931581e97ad, topicName=股骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee217064831, createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-18 zmjlilei

    感谢分享了么

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Oct 15 09:06:02 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148402, encodeId=133314840233, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 15 00:42:19 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362812, encodeId=4207136281238, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584873, encodeId=74c315848e3d7, content=<a href='/topic/show?id=931581e97ad' target=_blank style='color:#2F92EE;'>#股骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81797, encryptionId=931581e97ad, topicName=股骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee217064831, createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-17 zmjlilei

    非常感谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1848122, encodeId=2beb184812262, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Jan 15 00:16:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721826, encodeId=d6ed1e218260f, content=<a href='/topic/show?id=01811016363e' target=_blank style='color:#2F92EE;'>#骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101636, encryptionId=01811016363e, topicName=骨头)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Jun 21 17:16:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149908, encodeId=d5b214990848, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Oct 20 11:13:38 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149421, encodeId=81be1494214b, content=感谢分享了么, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Oct 18 08:32:46 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149155, encodeId=ad1d14915557, content=非常感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Oct 17 22:07:14 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148799, encodeId=99f5148e99a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Oct 16 10:54:46 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148498, encodeId=d05514849833, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Oct 15 09:06:02 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148402, encodeId=133314840233, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 15 00:42:19 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362812, encodeId=4207136281238, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584873, encodeId=74c315848e3d7, content=<a href='/topic/show?id=931581e97ad' target=_blank style='color:#2F92EE;'>#股骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81797, encryptionId=931581e97ad, topicName=股骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee217064831, createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-16 zmjlilei

    感谢分享一下

    0

  7. 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encryptionId=01811016363e, topicName=骨头)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Jun 21 17:16:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149908, encodeId=d5b214990848, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Oct 20 11:13:38 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149421, encodeId=81be1494214b, content=感谢分享了么, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Tue Oct 18 08:32:46 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objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Oct 15 09:06:02 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148402, encodeId=133314840233, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 15 00:42:19 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362812, encodeId=4207136281238, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584873, encodeId=74c315848e3d7, content=<a href='/topic/show?id=931581e97ad' target=_blank style='color:#2F92EE;'>#股骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81797, encryptionId=931581e97ad, topicName=股骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee217064831, createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-15 zmjlilei

    感谢分享一下

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Oct 15 09:06:02 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148402, encodeId=133314840233, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 15 00:42:19 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362812, encodeId=4207136281238, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584873, encodeId=74c315848e3d7, content=<a href='/topic/show?id=931581e97ad' target=_blank style='color:#2F92EE;'>#股骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81797, encryptionId=931581e97ad, topicName=股骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee217064831, createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-15 1e0ece0dm09(暂无匿称)

    谢谢谢谢分享

    0

  9. 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  10. 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createdName=huagfeg, createdTime=Fri Oct 14 13:16:00 CST 2016, time=2016-10-14, status=1, ipAttribution=)]
    2016-10-14 huagfeg