Neurology:短暂性脑缺血发作患者中风风险检查新方法

2017-06-08 zhangfan MedSci原创

血小板涂层检测是有效的短暂性脑缺血发作患者30天内中风风险预测手段

近日研究人员考察了胶原和凝血酶双重激动剂刺激血小板涂层检测对短暂性脑缺血发作患者30天内中风风险预测的效果。

研究连续招募短暂性脑缺血发作患者对其进行血小板涂层检测,主要终点是30天内中风发病。接受者操作特征(ROC)分析用于评估涂层血小板的预测的价值。

共招募患者171人,30天内发生10起中风事件。在51.1%的截至水平,血小板涂层检测的敏感度为0.80(95% CI 0.55-1.0),特异性为0.73 (95% CI 0.66–0.80), 阳性预测价值0.16 (95% CI 0.06–0.26), 阴性预测价值0.98 (95% CI 0.96–1.0)。涂层检测水平≥51.1%的患者相对于检测<51.1%的患者,其调整后中风风险为10.72。ROC显示,血小板涂层模型相比于现有的ABCD2得分对于中风预测更准确 (0.78 ± 0.07 vs 0.54 ± 0.07, p = 0.01)。

研究认为血小板涂层检测是有效的短暂性脑缺血发作患者30天内中风风险预测手段。

原始出处:

Angelia C. Kirkpatrick et al. Coated-platelets predict stroke at 30 days following TIA. Neurology. June 7 2017.

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    2017-08-12 yinhl1978
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  5. 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  6. 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  7. 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content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuEJWOf8El7MfqtlSpy4eWtPl5cxmNJ4ezwbFf5vtCeh53ITyabFpFIJfKTPlzdh6ibOibVONwHUbm9/0, createdBy=a4351715107, createdName=人间可客, createdTime=Fri Jun 09 09:04:22 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208534, encodeId=a423208534b2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Fri Jun 09 08:54:21 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208269, encodeId=aa212082696f, content=我觉得可以探讨着应用于临床,这也是一个很好的途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160911/IMG57D51CE461BD24798.jpg, createdBy=91d61672802, createdName=西风染林, createdTime=Thu Jun 08 21:43:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-10 jacob9231

    学习了谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1800815, encodeId=9e2818008151a, content=<a href='/topic/show?id=8a3be319614' target=_blank style='color:#2F92EE;'>#短暂性脑缺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73196, encryptionId=8a3be319614, topicName=短暂性脑缺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Tue Oct 24 10:56:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999968, encodeId=f85e199996843, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuEJWOf8El7MfqtlSpy4eWtPl5cxmNJ4ezwbFf5vtCeh53ITyabFpFIJfKTPlzdh6ibOibVONwHUbm9/0, createdBy=a4351715107, createdName=人间可客, createdTime=Fri Jun 09 09:04:22 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208534, encodeId=a423208534b2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Fri Jun 09 08:54:21 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208269, encodeId=aa212082696f, content=我觉得可以探讨着应用于临床,这也是一个很好的途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160911/IMG57D51CE461BD24798.jpg, createdBy=91d61672802, createdName=西风染林, createdTime=Thu Jun 08 21:43:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-09 人间可客

    学习了谢谢分享。

    0

  9. 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content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuEJWOf8El7MfqtlSpy4eWtPl5cxmNJ4ezwbFf5vtCeh53ITyabFpFIJfKTPlzdh6ibOibVONwHUbm9/0, createdBy=a4351715107, createdName=人间可客, createdTime=Fri Jun 09 09:04:22 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208534, encodeId=a423208534b2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Fri Jun 09 08:54:21 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208269, encodeId=aa212082696f, content=我觉得可以探讨着应用于临床,这也是一个很好的途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160911/IMG57D51CE461BD24798.jpg, createdBy=91d61672802, createdName=西风染林, createdTime=Thu Jun 08 21:43:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-09 jacob9231

    学习了谢谢分享

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208269, encodeId=aa212082696f, content=我觉得可以探讨着应用于临床,这也是一个很好的途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160911/IMG57D51CE461BD24798.jpg, createdBy=91d61672802, createdName=西风染林, createdTime=Thu Jun 08 21:43:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 西风染林

    我觉得可以探讨着应用于临床,这也是一个很好的途径

    0

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超过一半的人适合降脂、抗凝或抗高血压药物治疗,但在发生第一次卒中和短暂性脑缺血发作之前在处方中都没有写明需要服用这些药物。研究人员估计,如果通过将这些药物最佳时机写入处方,在英国每年约有12000次卒中事件可能会被预防。提高降脂、抗凝和抗高血压药物写入处方的比例是降低卒中和短暂性脑缺血发作发病率和负担的重要措施。

Stroke:收缩压与血管性痴呆的风险呈正相关

背景:血管性痴呆是第二大常见痴呆形式,但血压(BP)和血管性痴呆发生的风险特定年龄的相关性的可靠证据是有限的,一些研究报告在年龄较大的负面联想。方法:从电子初级保健健康档案(英国临床实践研究数据库)中识别无已知的心血管疾病和老年痴呆症428万人。研究者将BP和诊断血管性痴呆的时间联系起来。研究者在短暂性脑缺血发作和卒中(牛津血管研究)中进行潜在性的记录,探讨血压和老年痴呆症之间的关联。结果:随访时

Stroke: 短暂性脑缺血发作的流行病学调查

背景:最近几年短暂性脑缺血发作(TIA)流行病学可能发生了变化,对血管危险因素的识别和治疗得到改善。研究者旨在提供意大利TIA流行病学的最新信息。方法: 在基于人群的前瞻性登记记录中,识别2011年1月1日到2012年12月31日首发短暂性脑缺血发作的患者。拉奎拉地区所有居民TIA后,纳入研究并对其随访2年。结果事件包括TIA再发、非致死性和致死性卒中、非致死性和致死性心肌梗死和全因死亡率。结果:

Stroke:缺血性卒中或短暂性脑缺血发作患者发生脑微梗死危险因素有哪些?

最近有研究表明,脑微梗死(CMIs)可在体内使用3.0特斯拉(T)磁共振成像检测。研究人员调查了在缺血性卒中或短暂性脑缺血发作患者中,使用3.0T磁共振成像检测的大脑皮层CMIs的患病率,危险因素,和纵向认知结果。 该研究共包括231例接受3.0T磁共振成像的患者。蒙特利尔认知评估被用来评估总体认知功能和认知域(记忆,语言和注意视觉空间和执行功能)。蒙特利尔认知评分评估了基线和卒中/短暂

2016中国短暂性脑缺血发作早期诊治指导规范发作

短暂性脑缺血发作(Transient ischemic attack,TIA)是脑、脊髓或视网膜局灶性缺血所致的、未发生急性脑梗死的短暂性神经功能障碍,TIA与缺血性卒中有着密不可分的联系,大量研究显示,TIA患者在近期有很高的卒中发生风险。相关荟萃分析指出,TIA患者发病后第2天、第7天、第30天和第90天内的卒中复发风险分别为3.5%、5.2%、8.0%和9.2%,上述数据证实TIA是急性缺血

Stroke:缺血性卒中和短暂性脑缺血发作患者有很高的房颤风险

与缺血性卒中(IS)相比,房颤(AF)与短暂性脑缺血发作(TIA)之间的联系还没有被建立。该研究的目的是评估与IS患者相比,TIA患者发生房颤的比例,这些患者的特点,以及和二级预防治疗。 来自瑞典的研究人员分析了从2011年7月至2013年6月期间登记的TIA和IS事件基于医院的数据,这些数据从瑞典卒中注册(Riksstroke)获得。该研究也应用了基于时间的TIA定义(症状的持续时间&