JAHA:儿童体重指数的变化与成年期静脉血栓栓塞的风险

2019-03-15 xing.T 网络

由此可见,BMI持续高于平均水平的儿童在成年期患VTE的风险更高。虽然7-13岁的体重增加额外增加了VTE风险,但13岁时超重减轻会完全使升高的风险降至正常。

儿童体重变化轨迹可能影响心脏代谢特征,从而影响生命后期静脉血栓栓塞(VTE)的风险。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了儿童期超重和体重变化是否与成年期VTE风险相关。

研究人员使用丹麦医疗登记处对7-13岁且出生于1930-1989期间的丹麦学龄期儿童进行了一项基于人群的队列研究。研究人员基于体重和身高指标计算了体重指数(BMI)z分数,并使用Cox回归来估计风险比,以评估7-13岁的BMI z分数变化与随后的VTE风险之间的关联。

在313998名儿童中,5007名女孩和5397名男孩到成年期被诊断​为VTE。与两个年龄段BMI正常(25-75百分位数)的儿童相比,BMI持续高于75%的儿童成年后VTE风险增加1.30-1.50倍。经历BMI从第25百分位数增加到第75百分位数或从第75百分位数增加到第90百分位数到更高百分位数类别的儿童,其成年VTE风险增加1.35至1.70倍。7-13岁之间BMI百分位数下降的儿童成年VTE风险与BMI持续正常的儿童相似。

由此可见,BMI持续高于平均水平的儿童在成年期患VTE的风险更高。虽然7-13岁的体重增加额外增加了VTE风险,但13岁时超重减轻会完全使升高的风险降至正常。

原始出处:

Jens Sundbøll.et al.Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.011407

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    2019-04-06 xue8602
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    2020-01-26 fusion
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    2019-03-17 zhaohui6731
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    2019-03-16 12543c13m83暂无昵称

    谢谢分享

    0

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    2019-03-16 smartxiuxiu

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