JCEM：2型糖尿病女孩月经周期不规律发生率较高

2018-04-26 国际糖尿病编辑部国际糖尿病

根据发表于Endocrine Society's Journal of Clinical Endocrinology&Metabolism的一项新研究，被诊断为2型糖尿病的女孩月经周期不规律的发生率很高。

根据发表于Endocrine Society's Journal of Clinical Endocrinology&Metabolism的一项新研究，被诊断为2型糖尿病的女孩月经周期不规律的发生率很高。

月经失调的原因很多，包括妊娠、激素失衡、感染、疾病、创伤和某些药物。肥胖的成年女性有月经紊乱的风险，如多囊卵巢综合征（PCOS），可能导致糖尿病或其他代谢性疾病的发生，然而，年轻起病的2型糖尿病女孩生殖功能如何却鲜为人知，对于这部分患者，评估月经问题很重要，因为其可能痛经、脂肪性肝病、出现生育问题的风险增加，以及子宫内膜癌的长期风险增加。

为探索治疗年轻2型糖尿病患者的最佳方法，科罗拉多大学医学院的Megan Kelsey等对全国性研究——TODAY（Treatment Options for Type 2 Diabetes in Youth）研究的数据进行了二次分析，主要集中于评估新诊断2型糖尿病女孩月经不规律的频率，以及在二甲双胍治疗基础上强化生活方式干预或罗格列酮治疗是否有助于改善患者症状，而上述治疗通常用于治疗糖尿病和PCOS。

结果显示，TODAY研究中超过20%的女孩月经不规律，其中很多患者睾酮水平也很高，这表明PCOS是一个可能的原因；而TODAY研究中并非所有2型糖尿病女孩的睾酮水平都升高，提示月经失调还有其他原因。尽管经过了2年的二甲双胍单药治疗、二甲双胍加改变生活方式或者二甲双胍联合罗格列酮治疗，但参与者仍有明显的月经不规律。

该项研究表明，年轻起病的糖尿病女孩可能需要在治疗糖尿病之外进行额外干预，以改善其月经健康状况。

原始出处：

Megan M Kelsey, et al. Menstrual Dysfunction in Girls from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. Journal of Clinical Endocrinology & Metabolism. 24 April, 2018. DOI: 10.1210/jc.2018-00132.

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2018-05-25 achengzhao

#JCE#

39 0
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2018-12-07 一叶知秋

#发生率#

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2018-08-07 smallant2015

#JCEM#

42 0
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2018-04-28 惠映实验室

学习了.谢谢分享.

48 0
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2018-04-28 luwei00

#月经#

40 0
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2018-04-27 惠映实验室

学习了.谢谢分享.

54 0
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2018-04-27 溜溜梅不酸

轻起病的糖尿病女孩可能需要在治疗糖尿病之外进行额外干预.以改善其月经健康状况.

49 0
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2018-04-27 小贝熊

学习学习学习

65 0
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2018-04-26 有备才能无患

该项研究表明.年轻起病的糖尿病女孩可能需要在治疗糖尿病之外进行额外干预.以改善其月经健康状况.

49 0

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JCEM：2型糖尿病女孩月经周期不规律发生率较高

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