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Radiology：钆增强MR扫描后钆剂会出现在脑脊液中！

2018-07-18 shaosai MedSci原创

钆剂MR脑脊液
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本研究旨在评价是否在钆剂对比剂（GBCA）增强MR成像（MRI）后会渗透到脑脊液（CSF）中，并将结果发表在Radiology上。

本研究旨在评价是否在钆剂对比剂（GBCA）增强MR成像（MRI）后会渗透到脑脊液（CSF）中，并将结果发表在Radiology上。

本研究共分析了来自57例行钆特酸葡胺对比剂增强MRI检查且在之后60天内进行CSF取样患者（中位数年龄为50岁，范围3-92岁）的60份标本。分析行MRI平扫的患者（n = 22）或在行CSF抽样1年内行增强MRI检查的患者（n = 2）的CSF标本并作为对照。利用钆158同位素电感耦合等离子体质谱法侧列CSF指标。利用Kruskal-Wallis检验进行统计学分析。

结果为，在行GBCA增强8小时内的患者CSF中钆剂浓度要明显增高（平均浓度为1152 ng/mL ± 734.6）。在8-48小时候浓度降低。在48小时候，CSF中的钆剂几乎被完全清除(121 ng/mL ± 296.3)。其中有2/24例对照者中CSF标本为阴性。而对于行GBCA增强MRI检查超过1年后行CSF检查的患者浓度减低（1或3年后分别为0.1 and 0.2 ng/mL）。在慢性肾衰竭、脑弓形虫病和肝硬化的患者CSF中钆剂浓度要高。

本研究表明，钆特酸葡胺在静脉注射后可在人类CSF中检出。

原始出处：

Berger F， Kubik-Huch RA， Niemann T. et al.Gadolinium Distribution in Cerebrospinal Fluid after Administration of a Gadolinium-based MR Contrast Agent in Humans.Radiology.DOI：10.1148/radiol.2018171829

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    2018-09-30 ms1692810954239974

    #钆剂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1709936, encodeId=73e51e09936d4, content=<a href='/topic/show?id=879196253c6' target=_blank style='color:#2F92EE;'>#钆剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96253, encryptionId=879196253c6, topicName=钆剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d39d31820485, createdName=ms1692810954239974, createdTime=Sun Sep 30 18:32:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332416, encodeId=53ee3324165d, content=时间这么久啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Wed Jul 18 09:43:20 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332404, encodeId=389133240458, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jul 18 08:55:22 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332397, encodeId=658f33239e5b, content=学习学习涨见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:05:28 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332389, encodeId=8a5433238989, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jul 18 07:42:21 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332382, encodeId=380633238237, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jul 18 07:23:41 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332358, encodeId=b33f332358ec, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Jul 18 06:04:15 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332357, encodeId=1efb33235ef3, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Jul 18 06:04:13 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332347, encodeId=773733234e02, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:23:44 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 lyh994

    时间这么久啊

    0

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    2018-07-18 zb1235672

    学习了

    0

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    2018-07-18 liumin1987

    学习学习涨见识了

    0

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    2018-07-18 1209e435m98(暂无昵称)

    学习了谢谢分享

    0

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    2018-07-18 神功盖世

    阅

    0

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    2018-07-18 哈哈869

    学了

    0

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    2018-07-18 哈哈869

    学了

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    2018-07-18 yjs木玉

    好好好好好好好好

    0

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