Nat Med:可植入放电设备促进外周神经再生

2018-10-11 周舟 中国科学报

美国材料科学和神经外科领域研究人员共同开发出一种可植入、可降解的生物电医学设备。动物实验显示,它可以通过脉冲放电加速外周神经再生,促进受损外周神经恢复。

美国材料科学和神经外科领域研究人员共同开发出一种可植入、可降解的生物电医学设备。动物实验显示,它可以通过脉冲放电加速外周神经再生,促进受损外周神经恢复。

这项10月8日发表在英国《自然—医学》杂志上的研究由美国西北大学、华盛顿大学等机构研究人员完成。研究人员说,这种硬币大小、纸张厚度的无线控制设备植入机体后可工作数周,然后被机体自然吸收。设备可通过放电加速实验大鼠外周神经再生,促使肌肉力量和控制能力恢复。

事故或运动损伤等可能导致外周神经损伤,使伤者出现麻木、刺痛和虚弱等症状,有时需手术治疗。以往这类手术过程中会辅以电刺激促进康复,研究人员说,新设备可在手术完成后继续对受伤部位进行放电治疗。

论文共同作者、西北大学材料科学及工程学教授约翰·罗杰斯说,设备可“发挥剂量可控的积极治疗功能,随后没有痕迹地‘消失’在身体中”。

研究显示,这种柔性设备包裹着受伤神经,通过体外发射器无线供能并控制其在指定时间进行放电刺激。研究人员说,可通过调整材料组分和厚度控制设备发挥功能的天数,目前设备可使用数周。

原始出处;

Jahyun Koo, Matthew R. MacEwan, John A. Rogers, et.al. Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy. Nat Med 08 October 2018

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    2019-09-06 liye789132251
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    2018-10-13 jiyangfei
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