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Stroke：感染细小病毒B19是否与儿童动脉缺血性卒中有关？

2017-09-05 MedSci MedSci原创

细小病毒B19动脉缺血性卒中儿童
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一些病例对照研究表明，急性感染能够短暂增加儿童动脉缺血性卒中的风险。近期，一项发表在杂志Stroke上的研究评估了使用MassTag聚合酶链反应的无偏差病原体发现方法能否识别儿童动脉缺血性卒中病例血液中的病原体。此项研究为多中心国际VIPS研究（小儿卒中感染的血管影响）中入选的动脉缺血性卒中病例和无中风的对照人群，受试者年龄为29天至18岁。家长信息采集包括最近感染的相关问题。在此项试点研究中，研

一些病例对照研究表明，急性感染能够短暂增加儿童动脉缺血性卒中的风险。近期，一项发表在杂志Stroke上的研究评估了使用MassTag聚合酶链反应的无偏差病原体发现方法能否识别儿童动脉缺血性卒中病例血液中的病原体。


此项研究为多中心国际VIPS研究（小儿卒中感染的血管影响）中入选的动脉缺血性卒中病例和无中风的对照人群，受试者年龄为29天至18岁。家长信息采集包括最近感染的相关问题。在此项试点研究中，研究者们使用MassTag聚合酶链反应来测试前161例患者的血浆和34例对照组人群的28组常见细菌和病毒病原体。

最终，对照组中无病例，病例组中有14例（8.7％）检测到病原体DNA：细小病毒B19（n = 10），疱疹病毒6（n = 2），腺病毒（n = 1）和鼻病毒6C（n = 1）。细菌病毒B19感染在所有10例患者中均被血清学证实；亚临床上的感染有8例。细小病毒B19的4例患者患有先天性心脏病，而另外5例患者有明显的动脉病变，涉及颈内动脉和近端中脑动脉的长段狭窄。

此项研究表明：使用MassTag聚合酶链反应，在某些儿童动脉缺血性卒中病例中，可以检测到已知能够感染红细胞和内皮细胞的细小病毒B19。

原始出处：
Fullerton HJ, Luna JM, et al. Parvovirus B19 Infection in Children With Arterial Ischemic Stroke. Stroke. 2017 Sep 1. pii: STROKEAHA.117.018272. doi: 10.1161/STROKEAHA.117.018272.

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    2017-09-23 12498da4m32(暂无昵称)

    #缺血性卒#

    0

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    2018-07-13 xlysu

    #动脉缺血性卒中#

    0

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    2018-05-18 guihongzh

    #缺血性#

    0

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    2017-09-15 一个字-牛

    学习了谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1806181, encodeId=cdb41806181f5, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Sep 23 08:50:00 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776310, encodeId=5e1d1e76310a0, content=<a href='/topic/show?id=539633319e2' target=_blank style='color:#2F92EE;'>#动脉缺血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33319, encryptionId=539633319e2, topicName=动脉缺血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8138921016, createdName=xlysu, createdTime=Fri Jul 13 13:50:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892939, encodeId=478e1892939c4, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri May 18 04:50:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244229, encodeId=d2b624422934, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 15 08:16:44 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243834, encodeId=da1d243834ed, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Sep 14 08:09:16 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241634, encodeId=b122241634ab, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Sep 08 07:07:23 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240922, encodeId=ae34240922dc, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Sep 06 06:42:12 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-14 大爰

    学习了谢谢分享!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1806181, encodeId=cdb41806181f5, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Sep 23 08:50:00 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776310, encodeId=5e1d1e76310a0, content=<a href='/topic/show?id=539633319e2' target=_blank style='color:#2F92EE;'>#动脉缺血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33319, encryptionId=539633319e2, topicName=动脉缺血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8138921016, createdName=xlysu, createdTime=Fri Jul 13 13:50:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892939, encodeId=478e1892939c4, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri May 18 04:50:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244229, encodeId=d2b624422934, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 15 08:16:44 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243834, encodeId=da1d243834ed, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Sep 14 08:09:16 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241634, encodeId=b122241634ab, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Sep 08 07:07:23 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240922, encodeId=ae34240922dc, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Sep 06 06:42:12 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-08 yfjms

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1806181, encodeId=cdb41806181f5, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Sep 23 08:50:00 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776310, encodeId=5e1d1e76310a0, content=<a href='/topic/show?id=539633319e2' target=_blank style='color:#2F92EE;'>#动脉缺血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33319, encryptionId=539633319e2, topicName=动脉缺血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8138921016, createdName=xlysu, createdTime=Fri Jul 13 13:50:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892939, encodeId=478e1892939c4, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri May 18 04:50:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244229, encodeId=d2b624422934, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 15 08:16:44 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243834, encodeId=da1d243834ed, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Sep 14 08:09:16 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241634, encodeId=b122241634ab, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Sep 08 07:07:23 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240922, encodeId=ae34240922dc, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Sep 06 06:42:12 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 天地飞扬

    谢谢分享!

    0