Diabetic Med:妇女们早中期体重控制对于预防未来糖尿病的发展至关重要

2017-07-05 MedSci MedSci原创

近日,国际杂志 《Diabetic medicine》上在线发表一项关于绝经期过渡期间雌二醇和促卵泡激素水平的变化与糖尿病风险之间的关系的研究。

近日,国际杂志 《Diabetic medicine》上在线发表一项关于绝经期过渡期间雌二醇和促卵泡激素水平的变化与糖尿病风险之间的关系的研究。

研究人员对年龄在42-52岁的1407名绝经前妇女进行了调查,她们来自全国妇女健康研究(SWAN)调查的基线资料。糖尿病诊断依据空腹血糖水平,药物使用和医师诊断的自我报告。Cox比例风险回归用于评估糖尿病与激素变化率三个组成部分的关联:截距(绝经前水平)和两个分段斜率分别代表早期和晚期转换期间的变化。

15年的随访中,有132名妇女发展为糖尿病。调整潜在的混杂因素后,较高的雌二醇截距(而不是其变化率)与糖尿病风险降低[四分位数范围增加(75.2 pmol / L)的风险比为0.53,95CI 0.27-1.06]边界线显著相关。对于促卵泡激素,早期转移增加的增加率不高于截止或后期转移,与糖尿病风险降低显著相关[四分位数范围增加的危险比(5.9 IU / L /年)0.3195CI 0.10-0.94]

较低的绝经前雌二醇水平和较慢早期转换期间卵泡刺激激素变化与发生糖尿病的较高风险相关。鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。

原始出处:

S. K. Park, S. D. Harlow, H. Zheng,et al. Association between changes in oestradiol and follicle-stimulating hormone levels during the menopausal transition and risk of diabetes

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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 08 08:50:45 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607791, encodeId=abee160e791c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jul 07 14:40:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), 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  5. 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encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-09 杨利洪

    学习了分享了

    0

  6. 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encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-08 大爰

    学习并收藏谢谢!

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=219229, encodeId=f119219229f4, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jul 06 19:44:02 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219162, encodeId=9be72191623d, content=好好的看看有进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Jul 06 13:01:13 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219090, encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1637907, encodeId=fbd8163e90748, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Dec 03 21:40:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970504, encodeId=f07019e050416, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Sun Apr 08 13:40:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760098, encodeId=de7b1e600980a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Sep 12 01:40:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973626, encodeId=368019e3626d1, content=<a href='/topic/show?id=905526695ad' target=_blank style='color:#2F92EE;'>#体重控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 08 08:50:45 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607791, encodeId=abee160e791c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jul 07 14:40:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), 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encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 131****1460

    学习了受益匪浅。

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 08 08:50:45 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607791, encodeId=abee160e791c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jul 07 14:40:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), 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encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 忠诚向上

    好好的看看有进步

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 08 08:50:45 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607791, encodeId=abee160e791c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jul 07 14:40:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), 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encodeId=012921909037, content=鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Thu Jul 06 08:22:06 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 Julie W

    鉴于肥胖在糖尿病风险以及雌激素和促卵泡激素水平和变化方面在绝经期转换中起重要作用,因此早中期体重控制对于预防未来糖尿病的发展至关重要。

    0

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Diabetic Med:二甲双胍使用和糖尿病患者乳酸性酸中毒风险

近日,国际杂志 《Diabetic medicine》上在线发表一项关于二甲双胍使用及其在有无肾功能损害的糖尿病患者中乳酸中毒风险的队列研究。研究根据肾功能,评估二甲双胍使用者与其他降糖药物使用者的乳酸性酸中毒风险。

Diabetic Med:不同的临床预后因素与改善血糖控制有关

在中国新确诊的2型糖尿病患者中,二甲双胍和阿卡波糖对HbA 1c降低的初始治疗显示出相当的功效。然而,并不是所有参与者都能够实现血糖控制。近日,国际杂志 《Diabetic medicine》上在线发表一项关于不同的临床预后因素与改善血糖控制有关的MARCH随机试验的结果。研究人员目标是在基线特征的基础上确认2型糖尿病治疗反应的单一疗法预测因子。

Diabetic Med:一种以经验为基础的简易低血糖恐惧调查方法

近日,国际杂志 《Diabetic medicine》上在线发表一项关于开发一种以经验为基础的简易低血糖恐惧调查方法,以准确地衡量对低血糖的恐惧。

Diabetic Med:华南地区超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和风险增加

近日,国际杂志 《Diabetic medicine》上在线发表一项关于华南地区超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和风险增加的研究,目的在于调查超重和肥胖Ⅱ型糖尿病患者非酒精性脂肪性肝病的患病率和危险因素。

Diabetic Med:不同血压水平的Ⅱ型糖尿病患者的中风风险

近日,国际杂志 《Diabetic medicine》上在线发表一项关于基于人群的病例对照研究,以研究比较与瑞典一般人群相比,具有不同血压水平的Ⅱ型糖尿病患者的中风风险。

Diabetic Med:使用瑞典无烟烟草(鼻烟)对Ⅱ型糖尿病和成年潜伏性自身免疫性糖尿病(LADA)的风险

已经有研究表明,鼻烟(鼻烟)是一种普遍存在于斯堪的纳维亚尼古丁含量高的无烟烟草制品,它能够增加Ⅱ型糖尿病的风险。然而,之前相关的研究很少且存在矛盾,同时缺乏自身免疫性糖尿病相关的研究。本研究的目的是研究鼻烟使用与Ⅱ型糖尿病及成年潜伏性自身免疫性糖尿病(LADA)的风险之间的关系。