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JAHA：急性缺血性脑卒中患者血清MMP 9与认知功能损害之间的相关性分析！

2018-01-07 xing.T MedSci原创

缺血性脑卒中MMP9认知功能损害相关性
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由此可见，缺血性卒中急性期血清MMP 9水平升高与3个月认知功能障碍有关，并且独立于已知的危险因素。

血清基质金属蛋白酶9（MMP 9）对缺血性卒中后认知功能障碍的影响尚不清楚。近日，心血管疾病领域权威杂志JAHA上发表了一篇研究析文章，研究人员旨在探讨缺血性卒中急性期血清MMP 9水平与3个月时认知功能障碍之间的相关性。

该研究基于CATIS（中国急性缺血性脑卒中降压治疗试验）的子样本；研究将来自于CATIS研究中的26个地区中6个地区的558例测量了血清MMP 9水平的参与者纳入研究进行分析。认知功能障碍的严重程度分为重度、轻度、或无（简易精神状态评估得分分别为＜23, 23-26，或≥27；蒙特利尔认知评估得分分别为＜20、20-24或≥25）。认知功能受损被定义为蒙特利尔认知评估得分＜27分或简易精神状态评估得分＜25。

根据简易精神状态评分，143名（25.6%）参与者有轻度认知障碍，153名（27.4%）参与者在3个月内出现严重认知障碍。经过年龄、国家卫生研究院卒中评分、教育和其他协变量的调整后，血清MMP 9水平处于最高四分位数与最低四分位数相比的比值比为3.20（95%可信区间为1.87-5.49）。多元调整样条回归模型显示MMP 9水平与认知功能障碍呈线性关系（线性P＜0.001）。敏感性和亚组分析进一步证实了这些结果。当通过蒙特利尔认知评分评定认知功能障碍时也得到了类似的显著性结果。

由此可见，缺血性卒中急性期血清MMP 9水平升高与3个月认知功能障碍有关，并且独立于已知的危险因素。

原始出处：

Chongke Zhong,et al. Serum Matrix Metalloproteinase‐9 and Cognitive Impairment After Acute Ischemic Stroke.JAHA.2017. https://doi.org/10.1161/JAHA.117.007776

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    2018-04-23 guihongzh

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    2018-11-02 shenxlcyp

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    2018-05-09 weihongyv

    #脑卒中患者#

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11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-08-22 ms7524819409032184

    #缺血性脑#

    0

  5. 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11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-03-15 wangyang7969

    #卒中患者#

    0

  6. 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11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-01-09 snowpeakxu

    #急性缺血性脑卒中#

    0

  7. 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encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Wed Aug 22 18:14:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720220, encodeId=b3191e2022078, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Thu Mar 15 17:14:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259378, encodeId=b9e912593e87c, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267679, encodeId=43c7126e6797d, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-01-09 zhaohui6731

    #AHA#

    0

  8. 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encodeId=b9e912593e87c, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267679, encodeId=43c7126e6797d, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-01-09 anminleiryan

    #相关性分析#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1892997, encodeId=6c9a189299e4a, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Mon Apr 23 09:14:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837428, encodeId=7d45183e42812, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, 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encodeId=b9e912593e87c, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267679, encodeId=43c7126e6797d, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-01-08 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  10. 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11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523580, encodeId=a22f152358011, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Jan 09 11:14:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276535, encodeId=05782e6535b1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 08 07:10:57 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276438, encodeId=54542e643827, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Jan 07 21:44:15 CST 2018, time=2018-01-07, status=1, ipAttribution=)]
    2018-01-07 1e1b8538m79(暂无匿称)

    不错的文章.值得拥有

    0

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由此可见，他汀类药物的使用与既往有缺血性卒中或TIA病史的患者发生ICH的风险无关。

Neurology：缺血性脑卒中或TIA后千万别忽视戒烟！

吸烟有害健康。2017年9月，发表在《Neurology.》的一项前瞻性观察性队列研究调查了缺血性脑卒中或短暂性脑缺血发作（TIA）后戒烟与继续吸烟相比是否会改善结局。结果表明，缺血性脑卒中或TIA后戒烟或具有显著健康获益。

Stroke：急性脑卒中发作？赶紧去医院！脑卒中预后与发病到就诊时间间的相关性

在未进行再灌注治疗的患者中，早期及时就诊在提高脑卒中后临床预后的作用尚不清楚。本研究旨在验证在未行再灌注治疗或有小卒中的患者中早期及时入院就诊与良好预后间是否有相关性，并将结果发表在Stroke上。

华西医院科研团队找到治疗脑梗的新“靶标”

雷鹏团队经过三年多合作研究发现：“脑梗”患者在发病时，铁离子会聚集，导致铁稳态的紊乱。

Stroke：胰岛β细胞功能难道与非糖尿病患者缺血性脑卒中预后也有关系？

胰岛B细胞是胰岛细胞的一种，属内分泌细胞，约占胰岛细胞总数的70%，主要位于胰岛中央部，能分泌胰岛素，起调节血糖含量的作用。胰岛B细胞功能受损，胰岛素分泌绝对或相对不足，从而引发糖尿病。胰岛β细胞功能异常是II型糖尿病发生发展的一项重要因素。本研究旨在评估胰岛β细胞功能与缺血性脑卒中非糖尿病患者预后间的相关性，并将结果发表在Stroke上。