Gut:BTK激酶与食管癌

2017-08-24 zhangfan MedSci原创

研究认为BTK激酶是有效的抗食道癌靶点,目前ibrutinib治疗MYC 和(或) ERBB2过表达的中晚期食管癌的II期临床研究正在进行中

食管癌是全球癌症相关死亡的第七大因素,该疾病复发频繁且治疗选择有限。近日研究人员对食管癌相关生物标志物进行了研究。研究人员将17个食管癌细胞系的基因组图谱与小分子抑制剂药物敏感性数据相结合,确定与癌症驱动基因相关的药物敏感效应。研究同时考察了肿瘤细胞系RNA干扰数据,以确定候选基因依赖性或可作为治疗靶点的可能性。研究发现BTK 激酶具有潜在的食道癌治疗效果,BTK/ERBB2激酶抑制剂ibrutinib可显著抑制食道癌模型的疾病进展,在MYC以及ERBB2过表达细胞系中,ibrutinib 可以降低ERK介导的信号转导,抑制cMYC磷酸化,减低MYC蛋白水平,引起G1细胞周期阻滞和凋亡。研究认为BTK激酶是有效的抗食道癌靶点,目前ibrutinib治疗MYC 和(或) ERBB2过表达的中晚期食管癌的II期临床研究正在进行中。原始出处:Irene Yushing Chong et al. Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer . Gu

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    2017-09-07 1771ae4158m

    学习一下很不错

    0

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    2017-08-26 zhouqu_8
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    2017-08-26 redcrab
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    2017-08-26 fengting7
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objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Aug 24 23:06:14 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2017-08-25 刘煜

    学习了谢谢分享

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Aug 24 23:06:14 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2017-08-25 明月清辉

    谢谢分享.学习了

    0

  7. 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    2017-08-25 龙胆草

    学习谢谢分享

    0

  8. 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    2017-08-25 yfjms

    学习了

    0

  9. 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    2017-08-25 luominglian113

    学习了.谢谢分享

    0

  10. 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    2017-08-24 有备才能无患

    研究认为BTK激酶是有效的抗食道癌靶点.目前ibrutinib治疗MYC和(或)ERBB2过表达的中晚期食管癌的II期临床研究正在进行中.

    0

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