Eur Cell Mater：通过非病毒基因递送BMP-2/6和BMP-2/7形成异二聚体促进骨生成

2018-04-03 MedSci MedSci原创

非病毒基因传递是一种安全的技术以持续生理剂量的方式来释放骨形态发生蛋白（BMP）。多种BMP的共同递送可形成更有效的BMP异二聚体。在该研究中，研究人员评估了BMP-2/6和BMP-2/7的非病毒共转运，以产生异二聚体。使用编码BMP异构体（pBMP）的质粒DNA对山羊MSCs进行非病毒转染，已知与成骨有关的BMP异构体：BMP-2，-6或-7。结果，BMP-2，-6和-7可在MSCs中产生并且可

非病毒基因传递是一种安全的技术以持续生理剂量的方式来释放骨形态发生蛋白（BMP）。多种BMP的共同递送可形成更有效的BMP异二聚体。在该研究中，研究人员评估了BMP-2/6和BMP-2/7的非病毒共转运，以产生异二聚体。

使用编码BMP异构体（pBMP）的质粒DNA对山羊MSCs进行非病毒转染，已知与成骨有关的BMP异构体：BMP-2，-6或-7。结果，BMP-2，-6和-7可在MSCs中产生并且可检测长达14天，且其联合递送（pBMP-2与pBMP-6或pBMP-7）用于产生BMP-2/6和BM -2/7异二聚体。通过夹心酶联免疫吸附测定（ELISA）验证异二聚体蛋白的形成和分泌。

结果显示，产生的BMP和异源二聚体具有生物活性，细胞和MSCs的证实了这点。为了评估骨形成，将转染的MSCs接种到陶瓷支架上并将其皮下植入裸鼠中。在pBMP-2/6条件下骨形成明显增强，并且在pBMP-2/7和pBMP-6同二聚体条件下观察到更多骨形成的趋势。在pBMP-2，pBMP-7或对照条件中未发现骨。

总之，与BMP同型二聚体相比，用pBMP-6或-7同时递送pBMP-2可产生有利于骨形成的异二聚体。BMP序列的组合可以减少对高BMP蛋白剂量的需要并且可以延长生长因子的可用时间。

原始出处：

Loozen LD, Vandersteen A, et al., Bone formation by heterodimers through non-viral gene delivery of BMP-2/6 and BMP-2/7. Eur Cell Mater. 2018 Mar 28;35:195-208. doi: 10.22203/eCM.v035a14.

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#插入话题

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2018-09-24 HNYYM

#BMP#

35 0
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2018-08-15 维他命

#CEL#

29 0
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2019-01-29 hxj0117

#二聚体#

22 0
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2018-08-01 zhaozhouchifen

#Cell#

29 0
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2018-05-27 zhao4616

#非病毒#

40 0
[GetPortalCommentsPageByObjectIdResponse(id=1634029, encodeId=d01c1634029de, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Mon Sep 24 16:07:00 CST 2018, time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960802, encodeId=a8af196080249, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Aug 15 14:07:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950362, encodeId=d7af195036299, content=<a href='/topic/show?id=bfc624041dc' target=_blank style='color:#2F92EE;'>#二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24041, encryptionId=bfc624041dc, topicName=二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Tue Jan 29 17:07:00 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870534, encodeId=bbb618e0534cd, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Aug 01 07:07:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819560, encodeId=47e6181956082, content=<a href='/topic/show?id=7df79956800' target=_blank style='color:#2F92EE;'>#非病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99568, encryptionId=7df79956800, topicName=非病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba5f232, createdName=zhao4616, createdTime=Sun May 27 13:07:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642650, encodeId=fcf5164265047, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Fri Oct 12 02:07:00 CST 2018, time=2018-10-12, status=1, ipAttribution=)]
2018-10-12 12498f17m73暂无昵称

#BMP-2#

35 0

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Eur Cell Mater：通过非病毒基因递送BMP-2/6和BMP-2/7形成异二聚体促进骨生成

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