J Gastroen Hepatol:脂肪摄入与溃疡性结肠炎

2017-08-08 zhangfan MedSci原创

荟萃研究认为,脂肪摄入与溃疡性结肠炎之间不存在显著的相关性,但该结论需要大规模临床研究的确证

脂肪摄入与溃疡性结肠炎之间的关系一直存在争议。近日研究人员对脂肪摄入与溃疡性结肠炎(UC)之间的关系进行了考察。这是一项荟萃研究,研究通过剂量反应荟萃分析定量评价脂肪摄入在UC发展中的作用。9项相关研究纳入本次荟萃分析,其中对照研究4起,前瞻研究5起,共包含966名溃疡性结肠炎患者以及171589名对照志愿者。研究发现,脂肪摄入与UC风险不存在非线性剂量反应关系。总体而言,每天总脂肪摄入增加30g的UC相对风险增加1.023(95% CI: 0.963–1.087; I2=24%; n=6),饱和脂肪摄入增加风险为1.063 (95%CI: 0.845–1.337; I2=44.5%; n=4),单不饱和脂肪摄入增加风险为1.214 (95%CI: 0.911–1.618; I2=63.1%; n=4),多不饱和脂肪摄入增加风险为1.247 (95%CI: 0.948–1.640; I2=25.4%; n=4)。亚组以及敏感性分析表明,在调整吸烟状态后,多不饱和脂肪摄入与溃疡性结肠炎弱相关(RR: 1.617, 95%CI: 1.045–2.502; I2=0%; n=3)。对于多不饱

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    2018-03-02 许安
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    2018-06-23 nymo
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    2017-08-10 gwc384
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    2017-08-08 Julie W

    荟萃研究认为,脂肪摄入与溃疡性结肠炎之间不存在显著的相关性,但该结论需要大规模临床研究的确证。

    0

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