CSN:防治甲状旁腺功能亢进或改善肾移植预后

2012-05-10 范振光 医学论坛网

    2012年4月25-29日,加拿大肾脏病学会(CSN)年会上,加拿大不列颠哥伦比亚大学圣保罗医院的Howard Yan医生报告的一项研究表明,高钙血症是肾移植后常见并发症,可利用移植前临床和实验室数据进行预测;骨矿物质代谢紊乱与同种异体肾移植失败风险升高有关;预防和治疗高钙血症可能是改善肾移植预后的重要策略,有必要进行进一步研究。     研究者回顾了20

    2012年4月25-29日,加拿大肾脏病学会(CSN)年会上,加拿大不列颠哥伦比亚大学圣保罗医院的Howard Yan医生报告的一项研究表明,高钙血症是肾移植后常见并发症,可利用移植前临床和实验室数据进行预测;骨矿物质代谢紊乱与同种异体肾移植失败风险升高有关;预防和治疗高钙血症可能是改善肾移植预后的重要策略,有必要进行进一步研究。
 
  研究者回顾了2000年1月至2007年8月加拿大两家大型移植中心(多伦多总医院和温哥华圣保罗医院)的1352例连续成人同种异体肾移植(不合并其他移植)受者的病例资料。
 
  移植后1年内,约40%的患者至少出现1次高钙血症(定义为白蛋白校正后血清钙浓度≥2.6 mmol/L),12%的患者平均血清钙浓度≥2.6 mmol/L(移植后高钙血症)。
 
  多变量Logistic回归分析显示,以下因素与术后高钙血症的发生有关:年龄偏大、移植前血清钙浓度偏高、移植前甲状旁腺激素(iPTH)浓度偏高、移植前透析时间>5年。
 
  重复测量回归分析显示,移植后高钙血症患者估计肾小球滤过率(eGFR)每年降低1.81 ml/min/1.73m2,非高钙血症患者eGFR每年升高0.22 ml/min/1.73m2,差异无统计学意义。
 
  多变量回归分析显示,移植失败率升高与移植后高钙血症无关,但与移植前iPTH浓度升高有关。移植后iPTH数值未知。

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