J Periodontol:全口消毒对重度牙周炎患者龈沟液中的钙蛋白、骨钙蛋白和Ⅰ型胶原交联氨基末端肽的影响

2020-05-31 网络 网络

本研究旨在比较全口消毒(FMD)和全口超声清创术(FMUD)与传统刮治和根面平整(Q-SRP)对重度慢性牙周炎患者临床、微生物和生化指标的影响。

本研究旨在比较全口消毒(FMD)和全口超声清创术(FMUD)与传统刮治和根面平整(Q-SRP)对重度慢性牙周炎患者临床、微生物和生化指标的影响。

将60例慢性牙周炎患者随机分配到3个研究组。FMD(n = 20)、FMUD(n = 20)和Q-SRP(n = 20)。所有的临床检查和治疗均由同一研究者进行。在基线时,收集龈沟液(GCF)和龈下菌斑,并记录临床牙周参数。FMD组和FUD组在24小时内完成超声清创。FMD组使用了葡萄糖酸洗必泰。Q-SRP是通过手动器械进行,每周治疗1个象限。临床检测和取样在治疗后1,3,6个月后进行。实时PCR定量分析Aggregatibacter actinomycometemcomitans、Porphyromonas gingivalis、Prevotella intermedia、Tannerella forsythia、Fusobacterium nucleatum和总菌数。ELISA法分析GCF的钙保护蛋白、骨钙蛋白和Ⅰ型胶原交联氨基末端肽(NTx)水平。以治疗后GCF生物标志物水平的变化为主要结果。

结果发现,所有治疗组均有临床参数的显着改善(P<0.05),所有时间点均没有组间显着差异(P?0.05)。与FMD和Q-SRP相比,FMD和Q-SRP在6个月时的聚糖菌菌群显着减少(P <0.05)。虽然在研究期间,所有组的GCF NTx总量均有增加,但在治疗后的3个时间点上,全口治疗组的增加不明显(P<0.05)。

研究发现,全口治疗方法对微生物和生化参数的有益效果有限,但本研究仅代表了治疗的短期效果。这三种治疗方法都可以用于重度慢性牙周炎的治疗。

原文出处:

Beral Afacan,Full-mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N-telopeptide of Type I collagen in severe periodontitis, journal of periodontology, 2020 May, doi: 10.1002/JPER.19-0445

 

 

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    2020-12-18 feather89
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    2020-06-02 huperzia

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