J Dermatolog Treat:微针疗法联合富血小板血浆与Er: YAG激光治疗萎缩性瘢痕的疗效

2022-01-27 MedSci原创 MedSci原创

疤痕是自然愈合和修复过程的最终结果,影响患者的外在美观。皮肤微针疗法是一种不断发展的治疗方法,最初是为皮肤重塑而推出的。

疤痕是自然愈合和修复过程的最终结果,影响患者的外在美观。皮肤微针疗法是一种不断发展的治疗方法,最初是为皮肤重塑而推出的。富含血小板的血浆(PRP)是一种含有4-7倍人类血小板基线浓度的自体血浆溶液,已被用于各种皮肤病和非皮肤病的治疗,包括伤口愈合。近日,发表于J Dermatolog Treat的一项研究比较了微针疗法结合PRP与点阵式掺铒铝石榴石(Er: YAG)激光治疗创伤后萎缩性疤痕的疗效。

研究纳入了45名外伤后萎缩性疤痕患者,随机分为三组:第一组患者接受四个疗程的皮肤微针治疗,每个疗程后立即局部使用富血小板血浆(PRP)处理;第二组患者接受同样的治疗方案,但进行了六个疗程;第三组患者接受四次点阵Er: YAG激光治疗,间隔时间为4周,共四次治疗。使用四分法分级表对治疗反应进行临床评估,使用H&E染色、三色染色和Orcein特殊染色进行组织病理学评估。

 

结果显示,无论接受哪种治疗方法,所有患者都显示出明显的临床改善。第三组患者在临床和组织病理学改善方面显著优于第一组,但第一组和第二组之间以及第二组和第三组之间在改善方面都没有显著差异。

综上所述,该研究结果表明,点阵激光和微针疗法都是治疗创伤后萎缩性疤痕的安全且有效的疗法,微针疗法被证明与PRP一起使用比单独使用更有效,但它需要更频繁的治疗来达到最佳效果,达到与点阵激光类似的疗效。

 

原始出处:

 

N F Agamia, et al., Clinical and histopathological comparison of microneedling combined with platelets rich plasma versus fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser 2940 nm in treatment of atrophic post traumatic scar: a randomized controlled study. J Dermatolog Treat. 2021 Dec;32(8):965-972. doi: 10.1080/09546634.2020.1729334.  

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  5. 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content=<a href='/topic/show?id=26bd465e2e3' target=_blank style='color:#2F92EE;'>#富血小板血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46572, encryptionId=26bd465e2e3, topicName=富血小板血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Sat Jan 29 04:29:03 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434735, encodeId=5d041434e353f, content=<a href='/topic/show?id=817f66e686a' target=_blank style='color:#2F92EE;'>#激光治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66768, encryptionId=817f66e686a, topicName=激光治疗)], attachment=null, authenticateStatus=null, 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  6. 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content=<a href='/topic/show?id=26bd465e2e3' target=_blank style='color:#2F92EE;'>#富血小板血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46572, encryptionId=26bd465e2e3, topicName=富血小板血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Sat Jan 29 04:29:03 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434735, encodeId=5d041434e353f, content=<a href='/topic/show?id=817f66e686a' target=_blank style='color:#2F92EE;'>#激光治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66768, encryptionId=817f66e686a, topicName=激光治疗)], attachment=null, authenticateStatus=null, 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    2022-01-29 oliver169
  7. 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  8. 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