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Anal Chem：使用金纳米颗粒可实时评估细菌活力

2018-03-02 MedSci MedSci原创

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能够进行实时评估细菌活力对于多个领域很重要，如卫生管理，抗菌剂的开发以及细菌资源的有效利用。本研究中，研究人员展示了使用金纳米粒子（Au NP）评估细菌活力的简单方法。 含有Au NP的细菌悬浮液的颜色主要依赖于细菌活力。本研究发现，Au NPs与细菌分泌物质相互作用，Au NPs的分散状态影响悬浮液的颜色。肉眼很容易识别这种颜色变化，并通过测量特定波长处的吸光度来准确测定细菌的生存力。且不论它们

能够进行实时评估细菌活力对于多个领域很重要，如卫生管理，抗菌剂的开发以及细菌资源的有效利用。本研究中，研究人员展示了使用金纳米粒子（Au NP）评估细菌活力的简单方法。

含有Au NP的细菌悬浮液的颜色主要依赖于细菌活力。本研究发现，Au NPs与细菌分泌物质相互作用，Au NPs的分散状态影响悬浮液的颜色。肉眼很容易识别这种颜色变化，并通过测量特定波长处的吸光度来准确测定细菌的生存力。且不论它们是革兰氏阳性还是革兰氏阴性，这种方法都适用于各种细菌种类。

原始出处：

Kinoshita T, Ishiki K, et al., Real-Time Evaluation of Bacterial Viability Using Gold Nanoparticles. Anal Chem. 2018 Feb 28. doi: 10.1021/acs.analchem.7b05439. [Epub ahead of print]

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1633455, encodeId=fbd216334556f, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Mon Dec 03 05:48:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700064, encodeId=6f041e000643e, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Thu Nov 22 04:48:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323383, encodeId=cd9d1323383df, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun Mar 04 05:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-12-03 AspirantSuo

    #ANA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1633455, encodeId=fbd216334556f, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Mon Dec 03 05:48:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700064, encodeId=6f041e000643e, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Thu Nov 22 04:48:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323383, encodeId=cd9d1323383df, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun Mar 04 05:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-11-22 经常头晕

    #Anal#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1633455, encodeId=fbd216334556f, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Mon Dec 03 05:48:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700064, encodeId=6f041e000643e, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Thu Nov 22 04:48:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323383, encodeId=cd9d1323383df, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun Mar 04 05:48:00 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 ms3117646317107274

    #纳米颗粒#

    0