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J Allergy Clin Immunol：蛋白精氨酸甲基转移酶1能够促进过敏性鼻炎的发展

2021-02-06 AlexYang MedSci原创

分子机制过敏性鼻炎甲基转移酶
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精氨酸甲基化是由蛋白质精氨酸甲基转移酶(PRMTs)介导的一种翻译后修饰。虽然以前的研究表明，PRMT1与过敏性气道炎症或哮喘的严重程度有关，但其潜在的机制还不太清楚。

精氨酸甲基化是由蛋白质精氨酸甲基转移酶(PRMTs)介导的一种翻译后修饰。虽然以前的研究表明，PRMT1与过敏性气道炎症或哮喘的严重程度有关，但其潜在的机制还不太清楚。

最近，有研究人员探索了PRMT1在AR发展中的相关机制。研究结果表明，PRMT1的表达在AR患者和AR小鼠的鼻黏膜中显著增加。与野生型(WT)小鼠相比，PRMT1+/- AR小鼠鼻粘膜的嗜酸性浸润程度降低。PRMT1单倍体不足降低了血清中HDM特异性免疫球蛋白的水平，以及AR小鼠鼻腔灌洗液中Th2（IL-4、IL-5和IL-13）和上皮（TSLP、IL-25和IL-33）细胞因子的水平。在鼻腔上皮细胞中，HDM和IL-4一起通过一种丝裂原激活蛋白激酶（MAPK）依赖性途径能够增强PRMT1的表达。此外，PRMT1对HDM和IL-4刺激下TSLP、IL-25和IL-33的产生至关重要。AMI-1治疗能够缓解小鼠模型中的AR。

最后，研究人员指出，PRMT1通过调节上皮源性细胞因子的产生，在AR的发展中起着重要作用，可能是AR的一个新的治疗靶点。

原始出处：

Ji-Yeon Park， Joo-Hee Choi， Sang-Nam Lee et al. Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines. J Allergy Clin Immunol. Jan 2021

 

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    2021-03-16 gostraight

    #精氨酸#

    0

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    2021-10-20 hongbochen

    #过敏性#

    0

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    2021-12-04 yangfl06

    #甲基转移酶#

    0

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    2021-02-08 膀胱癌

    #ALL#

    0

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    2021-02-06 ms3000000449926787

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