Clinical Nutrition:健康的饮食模式及其相应的肠道微生物群特征与2型糖尿病风险较低有关

2019-03-11 不详 MedSci原创

糖尿病前期和老年人都是发生二型糖尿病(T2D)的高危因素,而肥胖是引发该疾病的最重要因素之一。营养干预是预防T2D的最有效工具,因为它可以促进/抑制肠道微生物群的增长。然而,到目前为止,没有具体的饮食建议来延缓老年人群中T2D的发展。因此,本项研究的目的是了解饮食模式对肥胖和非肥胖老年前驱糖尿病受试者的肠道微生物群特征的影响以及对T2D发生风险的影响。

背景
糖尿病前期和老年人都是发生二型糖尿病(T2D)的高危因素,而肥胖是引发该疾病的最重要因素之一。营养干预是预防T2D的最有效工具,因为它可以促进/抑制肠道微生物群的增长。然而,到目前为止,没有具体的饮食建议来延缓老年人群中T2D的发展。因此,本项研究的目的是了解饮食模式对肥胖和非肥胖老年前驱糖尿病受试者的肠道微生物群特征的影响以及对T2D发生风险的影响。

方法
研究人员对182名≥65岁,患有前驱糖尿病的受试者进行横断面研究,所有受试者被分为肥胖(OB)或非肥胖(NOB)组,根据FINDRISK评分和生化参数测量其发生T2D的风险。此外,通过PCA分析在每组中聚集成不同的饮食模式与肠道微生物群相关,其通过qPCR从粪便样品中分析。

结果
研究结果发现OB发生T2D的风险较高,并且代谢结果较差。从肠道微生物群获得的结果显示,只有普氏菌在NOB中较高,且与饮食模式有明显关联; 在较健康的膳食组中显示出普氏菌(Prevotella)的减少以及乳酸菌的增加。肥胖组中不健康膳食组的患T2D风险更大。

结论
健康膳食模式可以促进生长,促进有益肠道微生物群的生长,健康饮食对于高龄和DM前期的肥胖群体具有保护作用。

原始出处:

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time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362483, encodeId=9f8036248362, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Mar 12 06:38:30 CST 2019, time=2019-03-12, status=1, ipAttribution=)]
    2019-03-14 ren1mw

    学习了

    0

  5. 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    2019-03-12 1240394fm61暂无昵称

    很棒

    0

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