Am J Cardiol: 蛋白尿可预测显著冠脉狭窄

2012-08-14 高晓方译 医学论坛网

    韩国学者的一项研究表明,在伴有亚临床动脉粥样硬化的2型糖尿病患者中,蛋白尿为显着冠脉狭窄的独立预测因素。论文于2012年8月1日在线发表于《美国心脏病学杂志》(Am J Cardiol)。    此项研究共纳入232例伴有亚临床动脉粥样硬化的2型糖尿病患者,并均进行多层螺旋CT冠脉造影。通过颈动脉内中膜厚度(IMT)或颈动脉斑块确

    韩国学者的一项研究表明,在伴有亚临床动脉粥样硬化的2型糖尿病患者中,蛋白尿为显着冠脉狭窄的独立预测因素。论文于2012年8月1日在线发表于《美国心脏病学杂志》(Am J Cardiol)。
    此项研究共纳入232例伴有亚临床动脉粥样硬化的2型糖尿病患者,并均进行多层螺旋CT冠脉造影。通过颈动脉内中膜厚度(IMT)或颈动脉斑块确定亚临床动脉粥样硬化。
    结果显示,共有71例(31%)受试者伴有显着冠脉狭窄。伴有冠脉狭窄的受试者年龄较大,并且糖尿病持续时间较长。冠脉显着狭窄受试者的白蛋白/肌酐比(ACR)显着高于无显着冠脉狭窄的受试者。显着冠脉狭窄的年龄和性别校正比值比与伴有给定估计肾小球率过滤的蛋白尿成比例升高。作为连续变量或绝对变量的ACR与显着冠脉狭窄风险升高具有相关性,并且独立于传统心血管危险因素。在受试者工作特征分析中,ACR在预测显着冠脉狭窄方面对颈动脉IMT具有附加效应。

原文链接:

Son JW, Jang EH, Kim MK, Kim HL, Baek KH, Song KH, Yoo SJ, Yoon KH, Cha BY, Lee KW, Son HY, Kwon HS. Usefulness of Albuminuria as Predictor for Coronary Artery Stenosis, Regardless of Estimated Glomerular Filtration Rate, in Patients With Type 2 Diabetes Mellitus.Am J Cardiol. 2012 Aug 1.



    

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    2016-07-23 午夜星河

    认真学习

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    2016-03-02 忠诚向上

    看过来西

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