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AJOG：孕期睡眠呼吸障碍与婴儿神经运动发育

2015-01-20 Mechront 译 MedSci原创

孕期睡眠呼吸障碍婴儿神经
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相当一大部分女性怀孕期间经历过睡眠中断，特别是孕晚期，伴随着生理和体内激素的变化，更有可能发展为睡眠呼吸障碍（SDB）。而目前还没有关于孕期睡眠呼吸障碍和婴儿神经运动发育的研究，因此Riva Tauman等人进行了一项前瞻性研究以探究孕妇睡眠呼吸障碍对婴儿一般运动和神经发育的影响。研究成果发表于近期 Am J Obstet Gynecol 杂志上。研究者们从社区和医院招募孕晚期、产科监测低风险、没

相当一大部分女性怀孕期间经历过睡眠中断，特别是孕晚期，伴随着生理和体内激素的变化，更有可能发展为睡眠呼吸障碍（SDB）。而目前还没有关于孕期睡眠呼吸障碍和婴儿神经运动发育的研究，因此Riva Tauman等人进行了一项前瞻性研究以探究孕妇睡眠呼吸障碍对婴儿一般运动和神经发育的影响。研究成果发表于近期 Am J Obstet Gynecol 杂志上。

研究者们从社区和医院招募孕晚期、产科监测低风险、没有妊娠并发症的足月单胎妊娠孕妇和她们的婴儿作为研究对象。所有参与研究的孕妇在孕中期进行了有关睡眠的问卷调查，在孕晚期进行了睡眠研究。根据问卷调查和评估结果将参与者分为睡眠呼吸障碍组（SDB组：睡眠呼吸暂停低通气指数>5）和对照组。该研究分别在出生后48小时、8-11周、14-16周对婴儿进行一般运动的评估。在婴儿12月大时，对其进行了婴儿发育详情调查和简短的婴儿睡眠问卷调查。

该研究共纳入2009年3月——2012年3符合条件的74名女性和其足月生产儿。其中18名（18/74，24%）女性孕期有睡眠呼吸障碍，归于SDB组。平均新生儿出生体重为3347.1±423.9 g。出生后5分钟Apgar评分中位数为10。对于一般运动评估以及所有的3项连续评估，校正混杂因素后比较两组数据，没有发现显著性差异。在婴儿12月大时进行社会发展评估，SDB组有64%得分低，对照组有26%得分低（OR=16.7，调整后P=0.036）。同时，婴儿打鼾现象见在SDB组合对照组分别为41.7%、7.5%（P=0.004）。

初步研究结果显示，女性孕期伴有睡眠呼吸障碍并没有对新生儿和婴儿神经运动发育造成不良影响，但是值得注意的时，孕期伴有睡眠呼吸障碍可能会影响其后代在1岁时的社会发展，同时可能会导致婴儿打鼾率增加。


原始出处：

Tauman R1, Zuk L2, Uliel-Sibony S3, Ascher-Landsberg J4, Katsav S5, Farber M5, Sivan Y6, Bassan H3.The effect of maternal sleep-disordered breathing on the infant's neurodevelopment.Am J Obstet Gynecol. 2015 Jan 7. pii: S0002-9378(15)00002-2. doi: 10.1016/j.ajog.2015.01.001. [Epub ahead of print]


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    2015-11-09 zhanfl

    #睡眠呼吸#

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    2015-02-26 bbwznl

    #呼吸障碍#

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    2015-01-22 ms1343860338762272

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    2015-01-22 neurowu

    #发育#

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