J Hypertens:性激素与动态血压之间的关系

2018-06-26 xing.T MedSci原创

由此可见,只有在男性中,可以观察到总睾酮和SHBG与坐位DBP之间存在统计学显著性的横断面负相关性,并且与DHEAS水平呈显著正相关。

总睾酮水平较高和性激素结合球蛋白(SHBG)水平较低与女性血压升高(BP)相关,而男性总睾酮水平和血压之间呈负相关。很少有研究评估其与24小时动态血压(ABP)、夜间血压下降之间的关系或脱氢表雄酮硫酸盐(DHEAS)(作为雄激素前体)的作用。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员分析了229名参与了维生素D和Omega-3试验的正常血压男性(≥50岁)和女性(≥55岁)的基线血液样本。标准化的坐位血压(SBP和DBP)和24小时ABP由经过培训的技术人员进行测量。基线调查问卷报道了自我报告的心血管危险因素和社会人口学变量。根据年龄、种族/族裔、BMI、吸烟和饮酒调整的性别分层线性回归模型估计每种性激素与BP和24小时ABP指标之间的关联。Logistic回归分析用于评估与夜间血压降低的相关性(睡眠期间内SBP或DBP降低>10%)。

总睾酮和SHBG水平与SBP呈显著负相关,而DHEAS与BP无显著相关性。在男性中,多变量分析显示,DHEAS每增加10%与坐位DBP增加0.41mmHg相关(β=4.29,95%CI为0.84-7.73),总睾酮和SHBG每增加10%分别与坐位DBP降低0.54mmHg(β=-5.65,95%CI为-10.45至-0.84)和0.60mmHg(β=-6.30,95%CI为-11.38至-1.21)有关。在妇女中没有观察到显著的关联。

由此可见,只有在男性中,可以观察到总睾酮和SHBG与坐位DBP之间存在统计学显著性的横断面负相关性,并且与DHEAS水平呈显著正相关。

原始出处:

Jiménez, Monik C,et al. Association between sex hormones and ambulatory blood pressure.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Association_between_sex_hormones_and_ambulatory.97436.aspx

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    2019-04-25 feather89
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    2018-06-29 Jackie Li

    学习

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likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 26 07:52:45 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-27 大爰

    学习并分享!!

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 26 09:06:13 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327113, encodeId=30ad32e1133e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 26 08:52:40 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327095, encodeId=e03032e09546, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 26 07:52:45 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-27 12225669m29暂无昵称

    学习

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 26 09:06:13 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327113, encodeId=30ad32e1133e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 26 08:52:40 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327095, encodeId=e03032e09546, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 26 07:52:45 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 明月清辉

    谢谢分享.学习了

    0

  9. 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likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 26 07:52:45 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 龙胆草

    学习谢谢分享

    0

  10. 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likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 26 07:52:45 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 神功盖世

    0

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人类和小鼠的长周期自我更新造血干细胞(LT-HSCs)表达高水平的LH/绒毛膜促性腺激素受体(LHCGR),并且在LH刺激时这种受体会扩增。这个研究揭示了LH在调节HSC中的作用,并且为造血系统损伤后的造血恢复提供了新的治疗性方法。

JACC:性激素水平与绝经妇女心血管疾病风险的相关性研究

高水平的雄性激素和低水平的雌雄激素与女性心血管疾病(CVD)风险因素相关,但是研究女性性激素与CVD发生关系的结果存在不一致性。本研究的目的旨在评估性激素水平与无心血管疾病女性的CVD发生、冠心病发生和心衰发生的关系。本研究纳入了2834名(平均年龄为64.9 ± 8.9岁)MESA临床研究中的绝经妇女,其基线水平的睾酮、雌二醇、脱氢表雄酮和性激素结合球蛋白(SHBG)均有测量。经过平均12.1年

PLoS One:循环性激素与人体测量学、社会统计学和行为因素相关

性激素是许多疾病的病因。为了更好的理解疾病病因和疾病风险因素机制之间的相关性,最近,有研究人员进行了旨在调查人体测量学、社会统计学和行为因素与一些循环性激素和性激素结合球蛋白之间的相关性。研究包括了12330名年龄在25-85岁的来自25个研究的男性参与者。研究发现,更大的年龄与更高浓度的性激素结合球蛋白和二氢睾酮、以及更低浓度的硫酸脱氢表雄酮、游离睾酮、雄烯二酮和、雄甾烷二醇葡萄糖苷酸和游离雌二

性激素六项检验报告解读,这一篇就足够了!

在正常月经周期内六项性激素有各自不同的分泌曲线,不同的检测时间,会出现不同的检测结果,对每一项指标需要结合与其它激素的水平综合分析。