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Neurology病例：诊断挑战：晚发脊髓型脑腱黄瘤病

2019-03-30 zyx整理 神经科病例撷英拾粹

脊髓脑腱黄瘤病基因突变
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42岁女性，因下肢无力缓慢进展超过10年入院。查体提示痉挛性下肢瘫痪，双腿深感觉缺损，以及双手轻微意向性震颤。血液学和脑脊液检测未见明显异常。

42岁女性，因下肢无力缓慢进展超过10年入院。查体提示痉挛性下肢瘫痪，双腿深感觉缺损，以及双手轻微意向性震颤。血液学和脑脊液检测未见明显异常。内囊，大脑脚双侧对称病灶，长节段脊髓病变，特别是MRI上齿状核轻度受累（图），以及父母近亲结婚，提示脊髓型脑腱黄瘤病，尽管缺乏所有主要的系统受累表现，包括黄色瘤。血浆高胆甾烷醇水平（15μg/mL，正常范围0.45-3.75）和DNA测序提示CYP27A1基因新的纯合突变（p.L524R [c.1571T>G]），确诊本病。开始予鹅去氧胆酸治疗。

（图：FLAIR[A-B]和T2WI[D]可见内囊和大脑脚双侧对称高信号； T2WI可见背侧柱内纵向广泛高信号[E-G]，双侧齿状核轻度高信号[C，箭]，高度提示脊髓型脑腱黄瘤病）

原始出处：Mutlu D1, Tuncer A1, Gocmen R1, et al. Diagnostic challenge: A case of late-onset spinal form cerebrotendinous xanthomatosis. Neurology. 2019 Feb 26;92(9):438-439.

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    2019-07-30 yinhl1978

    #Neurol#

    0

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    2019-08-27 tm10051981

    #脑腱黄瘤病#

    0

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    2019-04-27 贪吃蛇大王

    好好学习天天向上

    0

  4. 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createdBy=76fa353, createdName=tm10051981, createdTime=Tue Aug 27 20:26:00 CST 2019, time=2019-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365342, encodeId=8d00365342d9, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 27 07:04:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365280, encodeId=5f7f3652808c, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Fri Apr 26 06:41:29 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365211, encodeId=1bb436521181, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Thu Apr 25 06:23:23 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365161, encodeId=9df036516187, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-26 贪吃蛇大王

    好好学习天天向上

    0

  5. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Fri Apr 26 06:41:29 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365211, encodeId=1bb436521181, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Thu Apr 25 06:23:23 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365161, encodeId=9df036516187, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-25 贪吃蛇大王

    好好学习天天向上

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-24 贪吃蛇大王

    好好学习天天向上

    0

  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Fri Apr 26 06:41:29 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365211, encodeId=1bb436521181, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Thu Apr 25 06:23:23 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365161, encodeId=9df036516187, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-23 贪吃蛇大王

    好好学习天天向上

    0

  8. 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createdBy=76fa353, createdName=tm10051981, createdTime=Tue Aug 27 20:26:00 CST 2019, time=2019-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365342, encodeId=8d00365342d9, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 27 07:04:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365280, encodeId=5f7f3652808c, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Fri Apr 26 06:41:29 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365211, encodeId=1bb436521181, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Thu Apr 25 06:23:23 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365161, encodeId=9df036516187, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-22 贪吃蛇大王

    好好学习天天向上

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Wed Apr 24 06:47:45 CST 2019, time=2019-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365103, encodeId=6908365103db, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Tue Apr 23 05:43:41 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365057, encodeId=f65a36505e23, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Mon Apr 22 06:21:12 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365007, encodeId=bf5d36500ef3, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sun Apr 21 06:11:14 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364928, encodeId=5011364928bd, content=好好学习天天向上，每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SrJSCPdKL0Ph25Lw3vlAkeSOJFyrKYpcmFTYHMla6icH6ibZ0zJHcbe2C5icyicow70stGsTm2efwfR6OibjYZD9N5A/132, createdBy=ff5a2004026, createdName=贪吃蛇大王, createdTime=Sat Apr 20 06:11:33 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-21 贪吃蛇大王

    好好学习天天向上

    0

  10. 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    2019-04-20 贪吃蛇大王

    好好学习天天向上，每天进步一点点

    0

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