CHEST:Arnold’s神经反射与慢性咳嗽的关系你知道么?

2017-12-12 MedSci MedSci原创

咳嗽是由于迷走神经支配的结构受到刺激后产生,这些结构包括气道和远端食道。阿诺德(Arnold’s)神经反射描述了通过刺激由迷走神经支支配的外耳道引起的咳嗽。既往的一些研究根据对耳鼻喉科门诊病人的观察,这种反射的发生率在2-3%之间,但在健康志愿者或慢性咳嗽患者中尚未被研究。近期,一项发表在杂志CHEST上的研究对这一问题进行了调查研究。研究者们对200名慢性咳嗽的成年人和100名慢性咳嗽患儿以及1

咳嗽是由于迷走神经支配的结构受到刺激后产生,这些结构包括气道和远端食道。阿诺德(Arnold’s)神经反射描述了通过刺激由迷走神经支支配的外耳道引起的咳嗽。既往的一些研究根据对耳鼻喉科门诊病人的观察,这种反射的发生率在2-3%之间,但在健康志愿者或慢性咳嗽患者中尚未被研究。

近期,一项发表在杂志CHEST上的研究对这一问题进行了调查研究。

研究者们对200名慢性咳嗽的成年人和100名慢性咳嗽患儿以及100名成人和100名儿科健康志愿者进行了评估,使用棉签涂抹器刺激受试者的每只耳朵的外耳道。在刺激的10秒内发生的咳嗽被认为是由刺激引起的。

此项研究结果显示:阿诺德的神经反射存在于25.5%的慢性咳嗽成人和3%的慢性咳嗽患儿中。而健康成人和儿童的反射率为2%。在慢性咳嗽成人中,女性(31.6%)比男性(12.5%)更常出现阿诺德神经反射,大部分患者(90.2%)为单侧。

此项研究结果表明:慢性咳嗽的成年人与健康者相比,阿诺德神经反射的发生率超过12倍,这一现象支持了咳嗽超敏反应综合征(CHS)的概念,其中提出迷走神经超敏反应是慢性难治性咳嗽的基础。儿童中,慢性咳嗽没有增加患病率表明CHS是一种获得性病症,其可能是由病毒性呼吸道感染或其他环境因素引起的。

原始出处:
Dicpinigaitis PV, Kantar A, et al. Prevalence of Arnold's Nerve Reflex in Adults and Children with Chronic Cough. Chest. 2017 Nov 29. pii: S0012-3692(17)33132-X. doi: 10.1016/j.chest.2017.11.019.

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    2018-07-14 Smile2680
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    2017-12-12 孙文杰

    学习了

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    2017-12-12 1e11f6a6m77(暂无匿称)

    学习

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