Stroke:社会经济地位影响卒中后功能障碍?

2015-02-08 李志行 译 MedSci原创

之前在社会经济剥夺程度与卒中后功能障碍关联方面的研究结果不一致,缺乏长期关联性的数据。我们通过年龄、性别、卒中前合并症和卒中表型这些方面来评估关联与差别。研究方法:我们采用伦敦南部卒中注册中心1995年至2011年间的数据进行队列研究,其中记录了所有伦敦西部各年龄患者首次发生卒中的案例。2104名患者在发生卒中3个月后仍在世。社会经济剥夺程度是通过以患者邮区号为基础的复合剥夺指数进行测量的,卒中后


之前在社会经济剥夺程度与卒中后功能障碍关联方面的研究结果不一致,缺乏长期关联性的数据。我们通过年龄、性别、卒中前合并症和卒中表型这些方面来评估关联与差别。

研究方法:


我们采用伦敦南部卒中注册中心1995年至2011年间的数据进行队列研究,其中记录了所有伦敦西部各年龄患者首次发生卒中的案例。2104名患者在发生卒中3个月后仍在世。社会经济剥夺程度是通过以患者邮区号为基础的复合剥夺指数进行测量的,卒中后功能障碍定义为巴氏量表<15。



研究结果:

在卒中发生三个月后,643名患者患有功能障碍(30.6%; 95% CI, 28.6%–32.5%)。与复合剥夺指数的第一组四分位数相比,第二、三、四组四分位数病人多元调整优势比为1.29 (95% CI, 0.94–1.76),1.33 (0.97–1.82), 和1.78 (1.31–2.43), 整体 P=0.004。关联在年龄≥65 岁的患者中十分显著(相应的优势比为 1.49 [1.02–2.17],1.21 [0.83–1.75], 和 1.94 [1.34–2.81]; P=0.003);在女性中,P=0.008,在没有卒中前合并症的患者中,P=0.009,在患有缺血性卒中的病人中,P<0.001,但是在其他类型的患者中,关联并不显著。社会经济剥夺程度与卒中三年后的损伤之间的关联模式也是相似的。




研究结论:

卒中后短期的和长期的功能恢复之间的不平等是显著的。总体上的社会经济水平提高时,有功能障碍高风险的目标群体有可能会降低卒中后功能恢复的不平等。

原始出处:

Ruoling Chen, Siobhan Crichton, Christopher McKevitt, Anthony G. Rudd, Anita Sheldenkar, and Charles D.A. Wolfe
Association Between Socioeconomic Deprivation and Functional Impairment After Stroke The South London Stroke Register
Stroke 2015; first published on February 3 2015 as doi:10.1161/STROKEAHA.114.007569

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    2015-02-16 windmilL1989

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    2015-02-08 115.231.229.**

    风险因素研究,但是社会经济地位可能影响了生活方式,及时治疗等决策行为

    0

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目前在房颤患者中左心室功能障碍(LVSD)、心力衰竭(HF)症状、栓塞风险之间关系方面的数据十分有限。研究方法:HF患者参与氯吡格雷联合厄贝沙坦预防房颤患者血管事件(ACTIVE)试验,但并不随机分配口服抗凝药物,他们被归类为保存射血分数型心衰和减低射血分数型心衰。如果是减低型,LVSD被分为轻度、中度或重度。症状通过纽约心脏病协会分级进行定量。主要结果为中风、短暂性脑缺血发作和全身性栓塞的综合。

Stroke:缺血性卒中在非持续性房颤患者中的表型

动态心脏检测的广泛应用不仅提高了对高风险心律失常,例如持久或阵发性房颤的检测水平,而且还使准确检测其他失常例如室上性心动过速的短暂(<30 秒) 不规则心率成为可能。缺血性卒中的表型可能会帮助我们理解这些非持续性片段在卒中病理生理学上所起到的作用,正如与其相应的持久或阵发的部分。研究方法:在一组连续的卒中患者中,我们回顾性地明确了与非持续性房颤有关的临床和影像学特征(n=126),定义为持续