ECC 2015：奥曲肽联合177Lu—DOTATATE对神经内分泌肿瘤可能有效（NETTER-1研究）

2015-10-01 MedSci MedSci原创

9月26日12:30，在ECC2015召开的第二次新闻发布会上，又有两项重要的最新研究摘要(LateBreakingAbstract)——RADIANT-4和NETTER-1研究亮相。在此对NETTER-1研究作一简介。          NETTER-1研究的主要研究者、同样来自美国的Philippe Ruszniewski教授指出，NET是

9月26日12:30，在ECC2015召开的第二次新闻发布会上，又有两项重要的最新研究摘要(LateBreakingAbstract)——RADIANT-4和NETTER-1研究亮相。在此对NETTER-1研究作一简介。

NETTER-1研究的主要研究者、同样来自美国的Philippe Ruszniewski教授指出，NET是一种起源于不同器官神经内分泌细胞的一组疾病。虽然NET较为罕见，但其却是胃肠道恶性肿瘤中第二常见的肿瘤，且近年来的发病率有增长。目前对一线生长抑素类似物治疗进展后的晚期中肠NET，治疗药物很有限，而肽受体放射治疗(PRRT)177Lu—DOTATATE靶向生长激素抑制素受体，Ⅲ期NETTER-1研究就探讨了177Lu—DOTATATE在上述患者中的应用价值。

研究共纳入229例患者，随机接受生长激素抑制素奥曲肽联合177Lu—DOTATATE治疗或单纯生长激素抑制素octreotideLAR。结果显示，前者的中位无进展生存(PFS)还未达到，后者的PFS期为8.4个月。目前的结果表明接受177Lu—DOTATATE治疗有额外的PFS获益。177Lu—DOTATATE组的客观缓解率(ORR)达到19%，而奥曲肽组为3%(P<0.0004)，中期分析的总生存(OS)也显示前者有延长趋势。Ruszniewski教授认为，鉴于在经治晚期中肠NET的有效治疗选择有限，该项Ⅲ期研究中的阳性结果使177Lu—DOTATATE成为了重要进展，该结果有望影响临床实践。

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2016-05-19 智慧医人

#奥曲肽#

35 0
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2016-08-05 12498e67m28暂无昵称

#TTE#

0 0
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2016-02-17 gwc392

#分泌#

0 0
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2016-07-25 1249898am27暂无昵称

#内分泌肿瘤#

26 0
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2016-05-02 lily1616

#神经内分泌#

21 0
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2016-04-29 仁医06

#ECC#

23 0
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2016-07-31 canlab

#NET#

24 0
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2015-10-03 bbjsj_1981

#ATA#

23 0

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ECC 2015：奥曲肽联合177Lu—DOTATATE对神经内分泌肿瘤可能有效（NETTER-1研究）

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