J Biomater Sci Polym Ed：新型功能化植体可更好的促进成骨分化

2018-06-24 MedSci MedSci原创

在这项研究中，我们开发了一种骨修复聚醚醚酮（PEEK）植入物，用丝素蛋白和骨形成肽修饰，其中生物聚合物PEEK植入物的表面首先被磺化以形成三维多孔形貌，然后使用丝素蛋白通过旋涂法和肽装饰功能化。生物测试结果显示，与未涂覆的细胞相比，功能性生物惰性植入物上的细胞表现出更好的细胞粘附、增殖和扩散。此外，肽修饰的丝素蛋白涂层具有促进成骨细胞样细胞的成骨分化和成熟的能力。综上所述，该研究结果表明，功能性

在这项研究中，我们开发了一种骨修复聚醚醚酮（PEEK）植入物，用丝素蛋白和骨形成肽修饰，其中生物聚合物PEEK植入物的表面首先被磺化以形成三维多孔形貌，然后使用丝素蛋白通过旋涂法和肽装饰功能化。

生物测试结果显示，与未涂覆的细胞相比，功能性生物惰性植入物上的细胞表现出更好的细胞粘附、增殖和扩散。此外，肽修饰的丝素蛋白涂层具有促进成骨细胞样细胞的成骨分化和成熟的能力。

综上所述，该研究结果表明，功能性PEEK植入物在骨科和牙科领域具有优异的生物活性和骨诱导性质的潜力。此外，简便的生物感应的骨生物修饰策略也可用于其他骨科和牙科植入物，例如钛，二氧化锆。

原始出处：

Wang C, Wang S, et al., Bioinspired, biocompatible and peptide-decorated silk fibroin coatings for enhanced osteogenesis of bioinert implant. J Biomater Sci Polym Ed. 2018 May 23:1-17. doi: 10.1080/09205063.2018.1477316.

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#插入话题

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2018-10-01 sunylz

#Bio#

49 0
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2018-12-16 HinsMax

#骨分化#

24 0
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2018-06-29 虈亣靌

优质资源.共同学习

49 0
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2018-06-26 ms5880526374914242

#成骨分化#

35 0
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2018-06-26 zhaojie88

#成骨#

36 0
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2018-06-24 1e0cf51fm76(暂无匿称)

是的呢

47 0
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2018-06-24 天地飞扬

了解一下.谢谢分享!

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