Reg Anesth Pain Med:围术期应用他汀类药物与全膝关节置换术后疼痛的关系

2019-12-06 anesthGH “罂粟花”微信号

目前尚不明确他汀类药物在围术期是否会增加或减少术后疼痛。本研究旨在探讨腰麻下全膝关节置换术后使用他汀类药物与疼痛的关系。

背景与目的

目前尚不明确他汀类药物在围术期是否会增加或减少术后疼痛。本研究旨在探讨腰麻下全膝关节置换术后使用他汀类药物与疼痛的关系。

方  法

这是一项基于2005年1月至2017年10月间三级医院病历记录的回顾性观察研究。我们分析了在腰麻下行选择性全膝关节置换术患者的住院病历。比较围术期服用他汀类药物的患者与未服用他汀类药物的患者术后3天(POD)的疼痛发生情况。

结  果

最终分析共纳入了1088例患者(544例为他汀类药物组和544例非他汀类药物组)。术后3天(POD)他汀类药物组总吗啡使用量高于非他汀类药物组(均值(标准差),他汀类药物组为525.4(119.7),而非他汀类药物组为495.3(115.3),95%CI 15.9~44.4,p<0.001)。线性回归分析显示,他汀组术后3天摄入的吗啡总量比非他汀组高30.14 mg (95% CI 15.93 ~ 44.35;p < 0.001)。

结  论

围术期他汀类药物的使用与腰麻下全膝关节置换术后阿片类药物用量的显着增加有关。

原始出处:

Tak Kyu Oh, Chong Bum Chang, Hyun-Jung Shin. Association between perioperative statin use and postoperative pain after total knee arthroplasty[J]. Reg Anesth Pain Med 2019;44:221–226

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  5. 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  6. 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  8. 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