感染

订阅

MedSci主页 / 所有栏目 / 感染

PNAS：科学家建立中东冠状病毒感染猕猴模型

2013-09-25 EurekAlert!中文 EurekAlert!中文

中东冠状病毒
关注

科研人员建立了致命的中东呼吸道冠状病毒感染的一个动物模型，它可能有助于发现中东呼吸综合征（MERS）的防护策略。自从中东呼吸综合征（MERS）在2012年6月于阿拉伯半岛出现以来，MERS-CoV β冠状病毒已经在中东和欧洲导致了超过108个人类病例，至少50人死亡，有多个人传人的报告。Vincent Munster及其同事建立了一个动物模型，它可能揭示出这种病原体如何导致疾病，并且可以帮助开


科研人员建立了致命的中东呼吸道冠状病毒感染的一个动物模型，它可能有助于发现中东呼吸综合征（MERS）的防护策略。【原文下载】

自从中东呼吸综合征（MERS）在2012年6月于阿拉伯半岛出现以来，MERS-CoV β冠状病毒已经在中东和欧洲导致了超过108个人类病例，至少50人死亡，有多个人传人的报告。

Vincent Munster及其同事建立了一个动物模型，它可能揭示出这种病原体如何导致疾病，并且可以帮助开发有效的疗法。这组作者为6只猕猴接种了已知最早的MERS-CoV分离株，称为HCoV-EMC/2012，这是从一名患有致命肺炎和急性肾衰竭的病人体内获得的。

这组作者报告说，在接受了气管内、眼、口和鼻内接种之后，这些猕猴出现了下呼吸道感染，随后出现了间质性肺炎和类似于人类对MERS-CoV做出反应的其他体征。

这项研究还确定了病毒复制的地点，发现了这种病毒在称为肺细胞的细胞中最剧烈地复制，肺细胞帮助维持肺的称为肺泡的小空腔。这组作者说，这种病毒对下呼吸道的偏爱可能有助于解释人类疾病的严重性以及相对有限的人间传播。


原文下载

Emmie de Wit, Angela L. Rasmussen, Darryl Falzarano, Trenton Bushmaker, Friederike Feldmannc, Douglas L. Brining, Elizabeth R. Fischer, Cynthia Martellaro, Atsushi Okumura, Jean Chang, Dana Scottc, Arndt G. Benecke, Michael G. Katze, Heinz Feldmann, and Vincent J. Munster.Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques.PNAS.2013 September 23.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1855442, encodeId=23091855442d3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sat Apr 19 07:55:00 CST 2014, time=2014-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636117, encodeId=320f163611ec2, content=<a href='/topic/show?id=26eb3092232' target=_blank style='color:#2F92EE;'>#冠状病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30922, encryptionId=26eb3092232, topicName=冠状病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53a422597656, createdName=zjshifan_98647313, createdTime=Fri Mar 07 08:55:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627216, encodeId=7008162e21614, content=<a href='/topic/show?id=705c682300e' target=_blank style='color:#2F92EE;'>#猴模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68230, encryptionId=705c682300e, topicName=猴模型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb521104186, createdName=wujh_7312826, createdTime=Fri Sep 27 04:55:00 CST 2013, time=2013-09-27, status=1, ipAttribution=)]
    2014-04-19 drwjr

    #PNAS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1855442, encodeId=23091855442d3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sat Apr 19 07:55:00 CST 2014, time=2014-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636117, encodeId=320f163611ec2, content=<a href='/topic/show?id=26eb3092232' target=_blank style='color:#2F92EE;'>#冠状病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30922, encryptionId=26eb3092232, topicName=冠状病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53a422597656, createdName=zjshifan_98647313, createdTime=Fri Mar 07 08:55:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627216, encodeId=7008162e21614, content=<a href='/topic/show?id=705c682300e' target=_blank style='color:#2F92EE;'>#猴模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68230, encryptionId=705c682300e, topicName=猴模型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb521104186, createdName=wujh_7312826, createdTime=Fri Sep 27 04:55:00 CST 2013, time=2013-09-27, status=1, ipAttribution=)]
    2014-03-07 zjshifan_98647313

    #冠状病毒感染#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1855442, encodeId=23091855442d3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sat Apr 19 07:55:00 CST 2014, time=2014-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636117, encodeId=320f163611ec2, content=<a href='/topic/show?id=26eb3092232' target=_blank style='color:#2F92EE;'>#冠状病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30922, encryptionId=26eb3092232, topicName=冠状病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53a422597656, createdName=zjshifan_98647313, createdTime=Fri Mar 07 08:55:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627216, encodeId=7008162e21614, content=<a href='/topic/show?id=705c682300e' target=_blank style='color:#2F92EE;'>#猴模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68230, encryptionId=705c682300e, topicName=猴模型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb521104186, createdName=wujh_7312826, createdTime=Fri Sep 27 04:55:00 CST 2013, time=2013-09-27, status=1, ipAttribution=)]
    2013-09-27 wujh_7312826

    #猴模型#

    0