Cell:科学家解密胰腺癌的转移机制,或可提前一步预防癌细胞转移!

2017-07-30 Heather_z727 来宝网

细胞,就像人一样是有有记忆。最初他们保留分子标记,这些生物标记的存在帮助指导他们的发展。细胞发生癌变很可能就是利用这些早期记忆权力转移的能力,并且在体内扩散到其他器官。


细胞,就像人一样是有有记忆。最初他们保留分子标记,这些生物标记的存在帮助指导他们的发展。细胞发生癌变很可能就是利用这些早期记忆权力转移的能力,并且在体内扩散到其他器官。

今日发表的研究结果为细胞的转移提供了强有力的证据,癌细胞转移是大多数癌症死亡的根本原因,特别适用于细胞参与最常见的胰腺癌类型,胰腺导管腺癌或PDA。

来自冷泉港实验室的研究团队证据癌细胞可以获取细胞传播的“记忆”,这就意味着每一个细胞,在某种意义上,都像上了膛的枪。在此次研究中,专注于胰腺细胞,因为几乎所有的胰腺癌转移能力都超强,也是胰腺癌过早死亡的原因所在,据统计,胰腺癌的五年生存率只有8%。

虽然癌症遗传原因很好理解,但是负责其转移的因素却是困扰科学界的一大难题,如今,研究人员以胰腺癌小鼠作为研究对象,将它们分为:癌变前的,癌症中,转移时三个小组,试图了解胰腺癌细胞的转移机制。

研究人员表示:“肿瘤的形成与遗传因素有关,但其传播的能力却不是DNA序列变化所直接导致的,这是我们此次分析胰腺癌细胞得出的结论。胰腺癌细胞转移时做的事情是需要记忆的,就像一个胚胎一样,FOXA1激活,诱导增强重组,赋予癌细胞转移性属性,这是一种表观遗传机制,而不是遗传,这也解释了胰腺癌的转移机制。”

相关文章:


原始出处:

Jae-Seok Roe, Chang-I Hwang, Tim D.D. Somerville, et al. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell, 2017.

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    2018-01-02 维他命
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    2017-08-02 大爰

    学习了谢谢分享!!

    0

  4. 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topicName=null, topicId=null, topicList=[TopicDto(id=97460, encryptionId=5c699e46010, topicName=防癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6d78400961, createdName=jeanqiuqiu, createdTime=Tue Aug 01 02:53:00 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595907, encodeId=b5a2159590e79, content=<a href='/topic/show?id=bdcfe153376' target=_blank style='color:#2F92EE;'>#癌细胞转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71533, encryptionId=bdcfe153376, topicName=癌细胞转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=365518309389, createdName=yinhl1984, createdTime=Tue Aug 01 02:53:00 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228461, encodeId=06d222846186, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 yxch36
  5. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Tue Aug 01 02:53:00 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455910, encodeId=2e44145591071, content=<a href='/topic/show?id=2920e8036d8' target=_blank style='color:#2F92EE;'>#细胞转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78036, encryptionId=2920e8036d8, topicName=细胞转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3415750271, createdName=zz72, createdTime=Tue Aug 01 02:53:00 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488024, encodeId=88e01488024d3, content=<a href='/topic/show?id=5c699e46010' target=_blank style='color:#2F92EE;'>#防癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 zz72
  6. 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 jeanqiuqiu
  7. 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GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1960345, encodeId=662519603455c, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 02 13:53:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870085, encodeId=f5d518e008515, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 清风拂面

    学习了,谢谢分享

    0

  9. 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 李东泽

    很好,不错,以后会多学习

    0

  10. 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channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 31 12:50:42 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228330, encodeId=cf692283308c, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 31 07:40:32 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228298, encodeId=68592282989c, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Mon Jul 31 06:25:30 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 laoli

    谢谢分享,学习了!

    0

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目前,胰腺癌已经在全球范围内成为了巨大的负担。我们其调查了胰腺癌的全球发病/死亡比率及其与社会经济发展之间的关系。总之,胰腺癌的发病率和死亡率在许多国家都在上升,需要定期监测。

Sci Transl Med:仅需10分钟60美元丨“癌中之王”可早期诊断了!

近日,一篇刊登在最新Science Translational Medicine杂志的文章报道了一种全新的胰腺癌血液检测技术,这项技术有望进一步实现对胰腺癌的早期诊断。

Sci Transl Med:“癌中之王”可早期诊断了!

近日,一篇刊登在最新Science Translational Medicine杂志的文章报道了一种全新的胰腺癌血液检测技术,这项技术有望进一步实现对胰腺癌的早期诊断。因为通常只有发展至晚期才能得到确切的诊断,胰腺癌的致死率远远高于其他大部分癌症。目前的大多数胰腺癌诊断技术都依赖于对胰腺癌细胞特定蛋白CA19-9的检测,而这种蛋白却往往只表达与晚期胰腺癌细胞。“CA19-9测试非常不完美。”研究对

Oncotarget:端粒酶和聚(ADP-核糖)聚合酶抑制剂联合使用能够限制胰腺癌细胞寿命

胰腺癌是一种恶性程度很高,约90%为起源于腺管上皮的导管腺癌,发病率和死亡率近年来明显上升,胰腺癌的诊断和治疗都比较困难,早期无特异性症状,手术死亡率较高,而治愈率很低。

盘点:癌中之王——胰腺癌近期重要研究进展汇总

胰腺癌通常在晚期阶段才被检测到,并且预后不良。按照医学界的说法,21世纪,胰腺癌已取代肝癌,成为新“癌王”。胰腺癌之所以被称为“癌王”,首先因为它发病率高,而且很难早期发现,一旦被发现50%以上是晚期;其次胰腺癌的死亡率很高,5年生存率不足5%,基本上每年有多少人被诊断出胰腺癌,就有多少人去世。这里梅斯小编整理了近期关于胰腺癌的重要研究进展与大家一同分享。【1】新技术让胰腺癌早期诊断准确度几近

Sci Tran Med:早期胰腺癌血液检测——将癌症杀灭在萌芽状态!

根据宾夕法尼亚大学佩雷尔曼医学院的新研究,新鉴定的生物标志物小组可以为早期检测和更好地治疗胰腺癌铺平道路。目前,美国每年有超过53,000人被诊断患有胰腺癌,这是癌症死亡的第四大原因。目前在科学转化医学中详细描述的血液生物标志物正确地检测了患者在不同疾病阶段的血液样本中的胰腺癌。