Gastroenterology:长期增加膳食纤维的摄入能降低老年妇女大便失禁的风险

2018-09-14 MedSci MedSci原创

目前,临床工作中医生经常把纤维补充剂用于治疗大便失禁(FI)的治疗中,但对膳食纤维在预防FI中的作用知之甚少。本项研究试图阐明膳食纤维在预防老年妇女大便失禁中的作用。

背景与目的
目前,临床工作中医生经常把纤维补充剂用于治疗大便失禁(FI)的治疗中,但对膳食纤维在预防FI中的作用知之甚少。本项研究试图阐明膳食纤维在预防老年妇女大便失禁中的作用。

方法
研究人员进行了一项前瞻性研究,以2008年全美护士健康研究中心数据库中58,330名年龄较大的女性(平均年龄73岁)为研究对象,对长期膳食纤维摄入量与FI风险之间的关系进行了相关分析。使用2006年更新的新版本食物频率调查表来确定受访者的膳食纤维摄入量。并使用自行管理的调查问卷将FI发生定义为过去4年中每月至少1次液体或固体FI发作。最后使用Cox比例风险模型根据纤维摄入量计算FI的多变量风险比。

结果
本项研究共进行了193,655人年的随访时间,研究人员记录了7,056例FI的事件。与纤维摄入量最低的五分之一(13.5克/天)的女性相比,最高五分位数(25克/天)的女性患FI的风险降低18%(OR:0.82; 95%CI:0.76- 0.89)。对于液体粪便FI的风险,这种下降的趋势似乎更加明显,与摄入量最低的女性相比,纤维摄入量最高的女性发生FI的风险下降31%(OR:0.69; 95%CI:0.62-0.75)。并且本项研究发现FI的风险的发生与纤维来源没有显着关联。

结论
通过本项研究,研究人员发现膳食纤维的长期摄入量增加与FI风险降低有关。当然这需要更大样本量的试验来进行验证。

原始出处:

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    2019-02-04 许安
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    2018-09-16 zhaojie88
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