Dig Liver Dis: 膳食中维生素E和C能减缓非酒精性脂肪性肝病的病情

2019-07-07 不详 MedSci原创

尽管抗氧化剂在非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)中具有保护作用,但关于膳食摄入抗氧化剂的作用的证据有限。本项研究的目的是探究膳食维生素E和C摄入量与NAFLD,NASH和纤维化标志物之间的关系。

背景和目标
尽管抗氧化剂在非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)中具有保护作用,但关于膳食摄入抗氧化剂的作用的证据有限。本项研究的目的是探究膳食维生素E和C摄入量与NAFLD,NASH和纤维化标志物之间的关系。

方法
研究人员通过超声检查判断所有的受试者是否患有NAFLD。使用SteatoTest,和FibroTest评分来评估肝脏病变程度,临界显着纤维化≥F1-F2来定义脂肪变性水平。通过食物频率问卷(FFQ)测量营养摄入量。

结果
本项研究共纳入789名受试者(52.6%男性,年龄58.83±6.58岁),调整BMI,饮食和生活方式因素,如果摄入达到推荐的维生素E的摄入量那么它与NASH之间存在负相关(OR = 0.48,0.30-0.77,P = 0.002)。维生素C摄入的上三分位数/ 1000千卡与NAFLD和NASH的较低几率相关(OR = 0.68,0.47-0.99,P = 0.045; OR = 0.57,0.38-0.84,P = 0.004)。

结论
维生素E和C的摄入可能对NAFLD相关的肝损伤具有保护作用。

原始出处:

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    2019-10-12 qjddjq
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    2019-07-09 zhaojie88
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