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Medicine：炎性生物标志物在诊断儿童和青少年胃炎中的作用

2020-03-03 不详 网络

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中性粒细胞与淋巴细胞的比率（NLR）是一种简单，无创，廉价的炎症标记，可用于评估炎症活性，尤其是在儿童年龄。本研究旨在建立经组织学证实的幽门螺杆菌（HP）与儿童NLR之间的相关性。在2016年4月至2018年1月之间，对来自罗马尼亚的三级儿科医院的137名年龄在1至18岁之间的小儿患者进行了前瞻性病例对照研究。根据组织学检查，将儿童分为两组：第1组：50例HP感染儿童，第2组：87例无任何病理学发

中性粒细胞与淋巴细胞的比率（NLR）是一种简单，无创，廉价的炎症标记，可用于评估炎症活性，尤其是在儿童年龄。本研究旨在建立经组织学证实的幽门螺杆菌（HP）与儿童NLR之间的相关性。

在2016年4月至2018年1月之间，对来自罗马尼亚的三级儿科医院的137名年龄在1至18岁之间的小儿患者进行了前瞻性病例对照研究。根据组织学检查，将儿童分为两组：第1组：50例HP感染儿童，第2组：87例无任何病理学发现的儿童。

研究组的平均年龄为12.86±3.796岁，而对照组的平均年龄为12.10±3.879岁（P = .3001）。在农村地区的儿童中，HP感染的发生率明显更高（P = 0.0089）。上腹疼痛和食欲不振与HP感染密切相关（P = .0350 / P = .0281）。我们注意到在第1组中白细胞和中性粒细胞计数明显更高（P = .0076 / P = .0306）。在淋巴细胞，红细胞沉降率，NLR或其他评估的实验室参数方面，两组之间无明显统计学差异。关于抗HP和快速脲酶的IgA抗体，均与组织学证实的HP感染密切相关（P <0.0001）。

总之，即使我们没有发现HP诱发的胃炎患儿与健康对照组之间在NLR方面存在显著差异，但平均NLR值是HP阳性患者较高。

原始出处：

Lorena Elena Meliţ, Maria Oana Mărginean, et al., The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis. Medicine (Baltimore). 2019 Jun; 98(26): e16188. doi: 10.1097/MD.0000000000016188

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    2020-08-20 lifestar

    #儿童和青少年#

    0

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    2020-09-17 jeanqiuqiu

    #DIC#

    0

  3. 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    2020-04-15 kalseyzl

    #CIN#

    0

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encodeId=a9da1610315d0, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380045, encodeId=22e03800454d, content=学习了，很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Mar 04 00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-25 hukaixun

    #标志物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1937507, encodeId=9b16193e507c2, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Aug 20 07:55:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859027, encodeId=9aa3185902e7a, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, 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encodeId=a9da1610315d0, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380045, encodeId=22e03800454d, content=学习了，很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Mar 04 00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-05 zhu_jun9842

    #生物标志#

    0

  6. 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577701, encodeId=626815e77019b, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610315, encodeId=a9da1610315d0, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380045, encodeId=22e03800454d, content=学习了，很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Mar 04 00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-05 zhu_jun9842

    #生物标志#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1937507, encodeId=9b16193e507c2, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Aug 20 07:55:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859027, encodeId=9aa3185902e7a, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, 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encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Mar 25 05:55:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560892, encodeId=5b1c15608927b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566901, encodeId=c45e156690141, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577701, encodeId=626815e77019b, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610315, encodeId=a9da1610315d0, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Mar 05 14:55:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380045, encodeId=22e03800454d, content=学习了，很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Mar 04 00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-05 ms1692212821629096

    #Medicine#

    0

  8. 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00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-05 ms3994565386320060

    #Med#

    0

  9. 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00:30:07 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-04 飛歌

    学习了，很有用不錯

    0