Diabetes Care：严重低血糖或与2型糖尿病患者癌症发生率较高相关

2014-02-13 晓静编译医学论坛网

中国香港学者探讨了2型糖尿病患者发生严重低血糖的临床情况与其临床转归(包括死亡和所有部位癌症发生)的相关性，结果表明，严重低血糖与高龄、肾功能不全、血糖控制不佳和癌症亚表现[低体质指数(BMI)、低水平的低密度脂蛋白胆固醇(LDL-C)和低甘油三酯(TG)]存在相关性。论文2月10日在线发表于《糖尿病护理》(Diabetes Care)杂志。【原文下载】研究纳入8767例在入组前的12

中国香港学者探讨了2型糖尿病患者发生严重低血糖的临床情况与其临床转归(包括死亡和所有部位癌症发生)的相关性，结果表明，严重低血糖与高龄、肾功能不全、血糖控制不佳和癌症亚表现[低体质指数(BMI)、低水平的低密度脂蛋白胆固醇(LDL-C)和低甘油三酯(TG)]存在相关性。论文2月10日在线发表于《糖尿病护理》(Diabetes Care)杂志。【原文下载】

研究纳入8767例在入组前的12个月内有或无严重低血糖的2型糖尿病患者。利用Cox比例风险模型计算严重低血糖的危险比(HR)和95%置信区间(Cis)。

结果显示，在研究队列中，患者的平均年龄为57.4岁，糖尿病中位患病时间为5年。在平均随访的6.71年间，有235例患者发生了严重低血糖(发生率为3.96例/1000人-年)。在入组时，有或无严重低血糖的患者癌症发生率相似。但在随访期间，与无严重低血糖的患者相比，有严重低血糖的患者所有部位癌症发生率(13.4 对6.4%，P< 0.0001)和死亡率(32.8对11.2%，P < 0.0001)均较高。校正混淆因素后，高龄、低BMI、高糖化血红蛋白、低TG、低LDL-C、蛋白尿和慢性肾病是严重低血糖的独立预测因素。

原始出处：

Kong AP, Yang X, Luk A, Ma RC, So WY, Ozaki R, Ting R, Cheung K, Ho CS, Chan MH, Chow CC, Chan JC.Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry.Diabetes Care. 2014 Feb 10. 【原文下载】

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2014-12-30 木头人513

#Diabetes#

31 0
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2014-03-04 ms9608593228839890

#DIA#

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2014-06-14 fmq_28614562

#严重低血糖#

0 0
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2014-05-06 一叶知秋

#发生率#

32 0
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2014-06-29 智智灵药

#BET#

38 0
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2014-02-15 zhouqu_8

#2型糖尿病患者#

24 0
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2014-02-15 xue8604

#糖尿病患者#

25 0

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