Diabetes Care:低血糖与老年T2DM患者认知减退相关

2013-10-29 佚名 丁香园

2型糖尿病患者处于增高的老年认知减退和痴呆的风险中。低血糖是其中的一个候选危险因素,但是严重低血糖事件与2型糖尿病患者认知减退的相关性尚未明确。因此,来自爱丁堡大学人口健康科学中心的Feinkohl等进行了一项研究,发现低血糖与老年T2DM患者认知减退有关。研究结果在线发表于2013年10月8日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】 在

2型糖尿病患者处于增高的老年认知减退和痴呆的风险中。低血糖是其中的一个候选危险因素,但是严重低血糖事件与2型糖尿病患者认知减退的相关性尚未明确。因此,来自爱丁堡大学人口健康科学中心的Feinkohl等进行了一项研究,发现低血糖与老年T2DM患者认知减退有关。研究结果在线发表于2013年10月8日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】

在爱丁堡2型糖尿病研究(ET2DS)中,研究人员对831名2型糖尿病患者(60-75岁)基线和4年后的认知功能进行了评估。以标准的一般能力因素“g”表示7项神经心理测试评分。记录基线自我报告的严重低血糖病史和随访期的严重低血糖事件。

结果显示,9.3%的受试者自我报告有低血糖病史;10.2%的报告低血糖事件。低血糖事件与基线认知能力差有关,经年龄和性别校正,g因素最低三分位数的患者发生低血糖的OR为2.04.随访期间,低血糖病史和低血糖事件均与更高的认知减退相关,与各自对应的对照组比较,有低血糖病史和低血糖事件的患者经年龄和性别校正的随访期和基线平均g分别为-0.25 vs.0.03和-0.28 vs.0.04,将协变量血管危险因素、心血管疾病和微血管疾病加入回归分析模型中,得到的结果相似。

研究表明,认知受损和低血糖之间的关系似乎很复杂,同时还伴有严重低血糖相关的早期认知能力差和认知减退加速。

原文出处:

Feinkohl I, Aung PP, Keller M, Robertson CM, Morling JR, McLachlan S, Deary IJ, Frier BM, Strachan MW, Price JF; on behalf of the Edinburgh Type 2 Diabetes Study (ET2DS) Investigators.Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study.Diabetes Care. 2013 Oct 8. 【原文下载】

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急性低血糖损伤多个方面的认知功能。执行认知功能管理思维组织、任务优先次序和时间安排。为了评价急性低血糖对糖尿病和非糖尿病成人的执行功能的影响,来自苏格兰爱丁堡皇家医院糖尿病科的Graveling等进行了一项研究,研究发现,1型糖尿病患者和非糖尿病受试者低血糖期间,进行日常活动所必须的执行认知功能受损。研究结果在线发表于2013年6月18日的美国《糖尿病治疗》(Diabetes Care)杂志上。

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严重低血糖是最佳血糖控制的最主要障碍。然而,近期治疗方法的改变可以导致严重低血糖流行病学和其相关危险因素变化。为了探讨当代1型糖尿病青少年儿童队列中严重低血糖相关发病率和危险因素,来自澳大利亚西澳大学Timothy W Jones教授及其团队进行了一项研究,该研究发现当代治疗方案与严重低血糖模式和发生率改变有关。该研究结果发表在2013年10月的《Diabetologia》