Eur Urol:不同预处理风险分层工具来预测前列腺癌死亡研究

2019-11-01 Alex Yang MedSci原创

前列腺癌疾病具有大量的预处理风险分层工具,而哪一种是最好的仍旧不清楚。最近,有研究人员系统的比较了最常使用的前列腺癌预处理风险分层工具在预后中的表现。研究的主分析共包括了139515名男性,其中15961名男性在跟踪调查期间死亡。10年跟踪调查期间的一致性指数(C-index)在不同的工具中范围为0.73(95% CI: 0.72-0.73)到0.81(95% CI: 0.80-0.81)。其中,

前列腺癌疾病具有大量的预处理风险分层工具,而哪一种是最好的仍旧不清楚。最近,有研究人员系统的比较了最常使用的前列腺癌预处理风险分层工具在预后中的表现。

研究的主分析共包括了139515名男性,其中15961名男性在跟踪调查期间死亡。10年跟踪调查期间的一致性指数(C-index)在不同的工具中范围为0.73(95% CI: 0.72-0.73)到0.81(95% CI: 0.80-0.81)。其中,MSKCC诺模图(C-index:0.81, 95% CI: 0.80-0.81)、CAPRA 评分(C-index: 0.80, 95% CI: 0.79-0.81)和CPG系统(C-index: 0.78, 95% CI: 0.78-0.79)表现最为出色。根据初级治疗和诊断年份的分层分析中包括了不同工具之间表现排序。另外,预测的累积发生率与观察的发生率接近,但在第5年有低估情况。研究人员指出了他们的研究的限制因素是只在单独的国家-瑞典进行。

最后,研究人员指出,MSKCC诺模图、CAPRA 评分和CPG系统在区分前列腺癌死亡中要比D'Amico和来源于D'Amico的系统(NICE、GUROC、EAU、AUA和NCCN)表现更好。这些工具的使用也许有助于改善临床决策。


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    2019-11-03 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2019-11-02 qingfengqishi5

    学习了,学习了

    0

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    2019-11-02 thm112988

    0

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    2019-11-02 飛歌

    学习了很有用不错

    0

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    2019-11-02 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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