Trends in Cancer：季红斌教授综述肺腺鳞癌转化的可能机制

2016-09-18 MedSci MedSci原创

2016年09月2日，中国科学院上海生命科学研究院生物化学与细胞生物学研究所季红斌研究员受邀在Trends in Cancer上发表题为“Squamous Transition of Lung Adenocarcinoma and Drug Resistance”的综述性论文，对肺腺鳞癌转化在肿瘤治疗耐药中的重要作用及其临床相关性进行了系统总结和研究展望。全球范围内肺癌的发病率和死亡率高居

2016年09月2日，中国科学院上海生命科学研究院生物化学与细胞生物学研究所季红斌研究员受邀在Trends in Cancer上发表题为“Squamous Transition of Lung Adenocarcinoma and Drug Resistance”的综述性论文，对肺腺鳞癌转化在肿瘤治疗耐药中的重要作用及其临床相关性进行了系统总结和研究展望。

全球范围内肺癌的发病率和死亡率高居不下。非小细胞肺癌(NSCLC)大约占肺癌总数的80％左右，其中肺腺癌和肺鳞癌是非小细胞肺癌中两类主要的亚型，它们在组织学特点、治疗手段等方面存在很大差异。近年来季红斌研究员课题组利用小鼠模型证实肺腺癌可以通过转化为肺鳞癌从而逃避药物杀伤，而这可能与肿瘤胞外基质重塑（ECM remodeling）及代谢重编程（metabolic reprogramming）密切相关 (Nat Commun 2014; Cancer Cell 2015)。最近这些动物模型中的研究发现得到了临床病例的有力支持。来自不同国家地区的11个临床病例报道肺腺癌在靶向治疗或化疗耐药后可以转变为肺鳞癌，提示肺腺鳞癌转化可能与治疗耐受有着重要的相关性。该论文充分结合基础前沿研究和临床观察，对肺腺鳞癌转化在肿瘤耐药中的重要角色进行阐述，并对后续肺腺鳞癌转化的临床研究提出了独到的见解。

该论文由侯申达女士、韩向琨博士在季红斌研究员的指导下完成，论文的编图得到了杨柳博士的大力支持。

Lung adenocarcinoma to squamous cell carcinoma transition and drug resistance in mouse model

原始出处：

Shenda Hou, Xiangkun Han, Hongbin Ji.Squamous Transition of Lung Adenocarcinoma and Drug Resistance.Trends in Cancer Volume 2, Issue 9, September 2016, Pages 463–466

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2017-08-03 ms1467340776200723

#ENDS#

34 0
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2017-03-08 freve

#trend#

26 0
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2016-09-27 童小孩

学习了，很受益，谢谢分享，继续关注中！

48 0
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channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Mon Sep 19 07:41:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130604, encodeId=b05013060417, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Sep 19 02:57:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130552, encodeId=a072130552a1, content=学习啦，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Sep 18 22:02:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130124, encodeId=205a130124f9, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130125, encodeId=40c41301259c, content=继续关注我们, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=)]
2016-09-20 1696533704_45270456

#鳞癌#

29 0
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createdBy=ced3193, createdName=freve, createdTime=Wed Mar 08 04:36:00 CST 2017, time=2017-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136280, encodeId=2eda1362806a, content=学习了，很受益，谢谢分享，继续关注中！, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 27 17:15:32 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484624, encodeId=40c21484624f3, content=<a href='/topic/show?id=3502102944e7' target=_blank style='color:#2F92EE;'>#鳞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, 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channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Mon Sep 19 07:41:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130604, encodeId=b05013060417, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Sep 19 02:57:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130552, encodeId=a072130552a1, content=学习啦，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Sep 18 22:02:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130124, encodeId=205a130124f9, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130125, encodeId=40c41301259c, content=继续关注我们, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=)]
2016-09-19 qixiaotong123

具体机制描述一下啊

49 0
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createdBy=ced3193, createdName=freve, createdTime=Wed Mar 08 04:36:00 CST 2017, time=2017-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136280, encodeId=2eda1362806a, content=学习了，很受益，谢谢分享，继续关注中！, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 27 17:15:32 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484624, encodeId=40c21484624f3, content=<a href='/topic/show?id=3502102944e7' target=_blank style='color:#2F92EE;'>#鳞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102944, encryptionId=3502102944e7, topicName=鳞癌)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20171006/a73877485ccdf6add82293e671bebe21.jpg, createdBy=745a7977375, createdName=1696533704_45270456, createdTime=Tue Sep 20 02:36:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130906, encodeId=5f181309061c, content=具体机制描述一下啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Mon Sep 19 16:07:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130693, encodeId=fac91306930f, content=哈哈，很好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Mon Sep 19 07:41:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130604, encodeId=b05013060417, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Sep 19 02:57:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130552, encodeId=a072130552a1, content=学习啦，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Sep 18 22:02:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130124, encodeId=205a130124f9, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130125, encodeId=40c41301259c, content=继续关注我们, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=)]
2016-09-19 1e0dde21m68(暂无匿称)

哈哈，很好！

53 0
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createdBy=ced3193, createdName=freve, createdTime=Wed Mar 08 04:36:00 CST 2017, time=2017-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136280, encodeId=2eda1362806a, content=学习了，很受益，谢谢分享，继续关注中！, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 27 17:15:32 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484624, encodeId=40c21484624f3, content=<a href='/topic/show?id=3502102944e7' target=_blank style='color:#2F92EE;'>#鳞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102944, encryptionId=3502102944e7, topicName=鳞癌)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20171006/a73877485ccdf6add82293e671bebe21.jpg, createdBy=745a7977375, createdName=1696533704_45270456, createdTime=Tue Sep 20 02:36:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130906, encodeId=5f181309061c, content=具体机制描述一下啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Mon Sep 19 16:07:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130693, encodeId=fac91306930f, content=哈哈，很好！, beContent=null, objectType=article, 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likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Sep 18 22:02:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130124, encodeId=205a130124f9, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130125, 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2016-09-19 忠诚向上

好好学习一下

44 0
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2016-09-18 医路开来

学习啦，，，

45 0
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2016-09-18 doctorJiangchao

继续学习

19 0
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topicList=[TopicDto(id=102944, encryptionId=3502102944e7, topicName=鳞癌)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20171006/a73877485ccdf6add82293e671bebe21.jpg, createdBy=745a7977375, createdName=1696533704_45270456, createdTime=Tue Sep 20 02:36:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130906, encodeId=5f181309061c, content=具体机制描述一下啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yqGyqlRsWYXXlASPpCvDxQIOj4U5ibyTGicNR5nTPxfE7J8CJLYEoTQiax0mdQk45PFsUH94hHxH18w/0, createdBy=96eb98305, createdName=qixiaotong123, createdTime=Mon Sep 19 16:07:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130693, encodeId=fac91306930f, content=哈哈，很好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Mon Sep 19 07:41:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130604, encodeId=b05013060417, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Sep 19 02:57:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130552, encodeId=a072130552a1, content=学习啦，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Sep 18 22:02:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130124, encodeId=205a130124f9, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130125, encodeId=40c41301259c, content=继续关注我们, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 18 13:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=)]
2016-09-18 doctorJiangchao

继续关注我们

23 0